Evidence map›Paper›PMID 40366478›Full record

ArticleMarine biotechnology (New York, N.Y.)2025

Three New α-Pyrone Derivatives with Antiepileptic Activity from the Marine Actinomycete Nocardiopsis sp. NBUDK19.

Jinling Li, Zhiyan Zhou, Fangjian Feng, Wei Yuan, Yawen Zhang, Jiaxing Wang, Bin Zhang, Haixiao Jin, Shan He, Lijian Ding

Abstract read
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In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinling LiSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Zhiyan ZhouSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Fangjian FengSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Wei YuanGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, China.
Yawen ZhangSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Jiaxing WangGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, China.
Bin ZhangGanzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, China.
Haixiao JinSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Shan HeSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Lijian DingSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China. dinglijian@nbu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a serious brain disease that urgently needs new drugs to treat it. In this study, three new α-pyrone derivatives, nocardipones A - C (1 - 3), were isolated from the sponge-associated actinomycete Nocardiopsis sp. NBUDK19 guided by anti-epileptic bioactivity using an in vivo zebrafish model. Compounds 1 - 3 were isolated and purified by silica gel column chromatography combined with semi-preparative HPLC. The structures of 1 - 3 were elucidated by UV, HRESIMS, NMR spectroscopic analysis, optical rotation, and computational chemical calculations. Our pharmacological study showed that compounds 1 - 3 exhibited notable reductions in seizure-like locomotor activity at 5 μg/mL. The qPCR analysis showed that compounds 1 - 3 significantly regulated the mRNA expression levels of c-fos and genes associated with GABAergic-glutamatergic signaling, including gria1b and gat1. The molecular docking revealed that compounds 1 - 3 strongly binding to 4-aminobutyric acid transaminase, with binding energies of - 7.3, - 7.8, and - 7.3 kcal/mol, respectively. This work enriches bioactive drug discovery to treat epilepsy and illustrates an underlying pharmacological and molecular mechanism of these natural α-pyrones.

Indexed as

ActinobacteriaAnticonvulsantsPyronesAnimalsMolecular Docking SimulationPoriferaZebrafishAnticonvulsantsPyronesAntiepileptic activityMolecular dockingNocardiopsisSecondary metabolitesZebrafish model

Identifiers

PMID40366478

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.