Evidence map›Paper›PMID 40366468›Full record

ArticleCell biology and toxicology2025

U2AF65 mediated circPVT1 promotes NSCLC cell proliferation and inhibits ferroptosis through the miR-338-3p/GPX4 axis.

Lujuan He, Zezhi Zhou, Jufen Wang, Jiehan Jiang, Shenggang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lujuan HeDepartment of Respiratory and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha City, 4100007, Hunan Province, P.R. China.
Zezhi ZhouDepartment of Respiratory and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha City, 4100007, Hunan Province, P.R. China.
Jufen WangDepartment of Respiratory and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha City, 4100007, Hunan Province, P.R. China.
Jiehan JiangDepartment of Respiratory and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha City, 4100007, Hunan Province, P.R. China.
Shenggang LiuDepartment of Respiratory and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha City, 4100007, Hunan Province, P.R. China. liushenggang0116@163.com.

Funding

Changsha Natural Science Foundation kq2208436Hunan Natural Science Foundation 2023JJ60073
6 · The paper itself

Abstract

backgroundDysregulation of circRNA expression is associated with increased metastasis and an adverse prognosis in non-small cell lung cancer (NSCLC). Herein, this study assessed the role and regulatory mechanism of circPVT1 in NSCLC development.

methodsCircPVT1 expression was determined using qPCR. Functional assays, including cell proliferation, colony formation, and ferroptosis-related measurements (ROS, MDA, SOD, GSH and Fe

resultsCircPVT1 was significantly elevated in NSCLC samples, correlating with worse clinical outcomes. Its knockdown resulted in diminished cell proliferation and increased ferroptosis. Mechanically, circPVT1 sponges miR-338-3p, facilitating GPX4 expression, which enhanced cell proliferation. U2AF65 bound to and stabilized circPVT1, promoting cell proliferation. In animal models, U2AF65 knockdown suppressed tumor progression by regulating the circPVT1/miR-338-3p/GPX4 signaling pathway.

conclusionsU2AF65 stabilizes circPVT1 to promote NSCLC advancement through miR-338-3p suppression and GPX4 upregulation. Thus, circPVT1 and U2AF65 may be potential therapeutic targets in NSCLC.

Indexed as

Carcinoma, Non-Small-Cell LungFerroptosisLung NeoplasmsMicroRNAsPhospholipid Hydroperoxide Glutathione PeroxidaseRNA, CircularRNA, Long NoncodingAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMicroRNAsMIRN338 microRNA, humanPhospholipid Hydroperoxide Glutathione PeroxidasePVT1 long-non-coding RNA, humanRNA, CircularRNA, Long NoncodingCircPVT1FerroptosisGPX4MiR-338-3pNSCLCU2AF65

Identifiers

PMID40366468
PMCPMC12078385

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