Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Quality of life and appraisal factors of patients with advanced cancer and their family caregivers.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Individualized Physiotherapy Improves Quality of Life and Symptom Burden in Advanced Cancer: A Quasi-Experimental Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- [The Impact of Parents' Autonomous Support on the Self-Identity of Adolescent Patients With Depression].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Health-Related Quality of Life and Related Characteristics of Informal Caregivers Providing Home Health Care to Elderly Patients: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Factors associated with anticipatory grief in family caregivers of patients with esophageal cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts.Epidemiology and psychiatric sciences · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeFew existing interventions have effectively improved the quality of life (QOL) for patients with advanced cancer and their caregivers, partly due to limited research on the factors associated with QOL. Guided by an adapted stress-coping model, this study aimed to examine the associations between the QOL of cancer patients and their caregivers and their primary and secondary appraisals. Primary appraisals involve perceptions and evaluations of advanced cancer and related caregiving, while secondary appraisals relate to their available resources and coping capabilities.
methodsUsing multi-level modeling, we conducted a secondary analysis of the baseline data collected from a randomized clinical trial that examined the effects of a family-based, psychoeducational support program for patients with advanced cancer and their caregivers (N = 362 dyads).
resultsThe appraisal variables hypothesized in the adapted stress-coping model explained 74.14% of the variance in the QOL of patients with advanced cancer and their caregivers when controlling for demographics and other disease-related variables. Better QOL in patients and caregivers was associated with less negative appraisals of illness/caregiving, less uncertainty and hopelessness, less avoidant coping strategies, more family support, more health behaviors, higher self-efficacy, and more active coping strategies.
conclusionOur study highlights the significant impact that advanced cancer has on patients and their caregivers' perceptions, responses to the illness, and QOL. Future interventions may benefit from addressing illness/caregiving appraisals, uncertainty, hopelessness, family support, health behaviors, self-efficacy, and coping strategies. However, further research is needed to determine the effectiveness of interventions specifically targeting these factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.