Evidence map›Paper›PMID 40366396›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

HSPB1/KDM1 A facilitates ANXA2 expression via hypomethylated DNA promoter to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer.

Liuxu Yang, Ruizhe Wang, Lun Zhang

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Liuxu YangDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an JiaoTong University, Xian, Shaanxi, 710061, China.
Ruizhe WangHealth Science Center, Xi'an JiaoTong University, Xian, Shaanxi, 710061, China.
Lun ZhangDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an JiaoTong University, Xian, Shaanxi, 710061, China. zhanglun3781@stu.xjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy resistance contributes to the unsatisfied prognosis in pancreatic cancer (PC) patients. Heat shock protein beta-1 (HSPB1) plays a tumor promoting role in PC by inhibiting ferroptosis. This study aims to explore whether high expression of HSPB1 was responsible for ferroptosis and gemcitabine (GEM) resistance in PC. Here, we found that HSPB1 was upregulated in GEM-resistant PC cells and tumor tissues, as confirmed by RT-qPCR and Western blotting assays. Knockdown of HSPB1 enhanced GEM sensitivity, decreased the abilities of proliferation and invasion, and promoted apoptosis in GEM-resistant PC cells. Utilizing commercial kits, HSPB1 inhibition triggered ferroptosis, as indicated by increased levels of reactive oxygen species, malondialdehyde, and Fe

Indexed as

Annexin A2Antimetabolites, AntineoplasticDeoxycytidineFerroptosisHeat-Shock ProteinsHSP27 Heat-Shock ProteinsPancreatic NeoplasmsAnimalsCell Line, TumorDNA MethylationDrug Resistance, NeoplasmFemaleGemcitabineGene Expression Regulation, NeoplasticHumansMaleAnnexin A2Antimetabolites, AntineoplasticANXA2 protein, humanDeoxycytidineGemcitabineHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHSPB1 protein, humanMolecular ChaperonesANXA2FerroptosisGemcitabine resistanceHSPB1HypomethylationKDM1 APancreatic cancer

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.