Evidence map›Paper›PMID 40366358›Full record

ArticleAndrology2026

Low testosterone in primary infertile men is associated with a history of maternal obesity during pregnancy: Findings from a cross-sectional study.

Fausto Negri, Luca Boeri, Edoardo Pozzi, Massimiliano Raffo, Riccardo Ramadani, Gabriele Birolini, Federica Passarelli, Christian Corsini, Federico Belladelli, Alessandro Bertini and 5 more

Abstract read
In one paragraph

Article in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fausto NegriDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID 0000-0002-3677-6412
Luca BoeriDepartment of Urology, IRCCS Fondazione Ca' Granda, Policlinico di Milano, Milan, Italy.ORCID 0000-0003-0040-784X
Edoardo PozziDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID 0000-0002-0228-7039
Massimiliano RaffoDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Riccardo RamadaniDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Gabriele BiroliniVita-Salute San Raffaele University, Milan, Italy.
Federica PassarelliDepartment of Urology, IRCCS Fondazione Ca' Granda, Policlinico di Milano, Milan, Italy.
Christian CorsiniDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID 0000-0001-9603-1589
Federico BelladelliDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID 0000-0002-2165-659X
Alessandro BertiniDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Rayan MatloobDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Alessia d'ArmaDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Michael L EisenbergDepartment of Urology, School of Medicine, Stanford University, Stanford, California, USA.ORCID 0000-0001-5482-0141
Francesco MontorsiDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Andrea SaloniaDivision of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID 0000-0002-0595-7165

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal obesity increases offspring obesity risk, but limited data exist on its association with reproductive hormones in infertile males.

objectivesTo investigate the impact of maternal obesity during pregnancy on total testosterone levels in primary infertile men. MATERIALS AND

methodsData from 418 men seeking medical help for primary infertility were analyzed. Demographics, clinical data, comorbidities, and history of maternal obesity during pregnancy were recorded. Testicular volume was assessed with Prader's orchidometer. Serum hormones, including calculated free testosterone, and semen parameters were collected. Low testosterone and low calculated free testosterone were defined as total testosterone <3 ng/mL and calculated free testosterone <120 pg/mL. Descriptive statistics and regression models evaluated associations between maternal obesity at pregnancy and both total testosterone and calculated free testosterone levels.

resultsMedian (interquartile range) age and body mass index were 36 (33‒40) years and 24.8 (23.1‒26.8) kg/m

conclusionsLow testosterone is a frequent characteristic in primary infertile men. Although rare, maternal obesity at pregnancy is significantly associated with reduced total testosterone and calculated free testosterone levels. Further preventive strategies and close follow-up should be considered in this specific group.

Indexed as

Infertility, MalePregnancy in ObesityTestosteroneAdultBody Mass IndexCross-Sectional StudiesFemaleHumansMalePregnancySex Hormone-Binding GlobulinTestisSex Hormone-Binding GlobulinTestosteronefree testosteronelow testosteronemale infertilitymaternal obesityreproductive health

Identifiers

PMID40366358
PMCPMC12917575

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.