Evidence map›Paper›PMID 40366311›Full record

ArticleClinical anatomy (New York, N.Y.)2026

Variations in Human Trigeminal and Facial Nerve Branches and Foramina Identified by Dissection and Microcomputed Tomography.

Hannah L Grimes, Valentina Pizzuti, Maria A Wright, Kane P J Colston, Thomas Santarius, Susan Jones

Abstract read
In one paragraph

Article in Clinical anatomy (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah L GrimesDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Valentina PizzutiDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Maria A WrightDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Kane P J ColstonBristol Veterinary School, University of Bristol, Bristol, UK.
Thomas SantariusDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Susan JonesDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-4130-8111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to identify branches of the trigeminal and facial nerves (FNs) relevant to surgical incisions and injections and the scalp block techniques in the frontotemporal region, and to determine their relationships with superficial vascular structures and bony landmarks. Half-heads from consenting embalmed donors (6 male, 2 female, mean age at death 78.4 years) were used in this study. Detailed dissection was carried out to identify the position of the auriculotemporal nerve (ATN) relative to the superior temporal artery (STA) and the FN in six subjects (5 male, 1 female). The results provide a minimum safe distance of 5 mm between the STA and the frontotemporal branches of the FN at the level of the low edge of the zygoma and 8 mm between the low edge of the zygoma and the FN trunk, providing a pre-auricular triangle of safety for incisions and injections. Variability between subjects was up to 60%. Microcomputed tomography (microCT) scans were taken from all eight subjects and the three-dimensional reconstructions were used to identify the supraorbital notch (SON), the zygomaticotemporal foramen (ZTF), and the zygomaticofacial foramen (ZFF). The volume and relative locations of these foramina were calculated for 5-8 subjects. The closest distance between ZTF and the frontozygomatic suture (FZS) ranged from 9 to 21 mm (26% variation); 3 subjects had a single ZTF while 5 subjects had two ZTF. The angle at the center of the orbit between ZFF and the FZS ranged from 156° to 166° (2.5% variation). These findings demonstrate that both traditional cadaveric dissection methods and contemporary microCT methods can be used to investigate the relative locations of nerves or their foramina in the human head. The findings provide anatomical considerations for fronto-temporal incisions and local anesthesia.

Indexed as

Anatomic VariationFacial NerveTrigeminal NerveAgedAged, 80 and overCadaverDissectionFemaleHumansMaleX-Ray Microtomographyauriculotemporal nerveawake surgeryfacial nervemicroCTscalp blocktrigeminal nerve

Identifiers

PMID40366311
PMCPMC13584668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.