SynthesisCritical care explorations2025
Critical Care Ultrasonography for Volume Management: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Trials.
Synthesis in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Fluid Creep as an Independent Predictor of Fluid Overload and Mortality in Critically Ill Patients: A Cohort Study.Life (Basel, Switzerland) · 2025Article
- Critical care ultrasound: development, evolution, current and evolving clinical concepts in critical care medicine.Frontiers in medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the safety and efficacy of critical care ultrasonography (CCUS) guided volume management in acutely ill patients. DATA SOURCES: We searched MEDLINE, Embase, Wiley CENTRAL, and unpublished sources from inception to February 6, 2024. STUDY SELECTION: We included randomized controlled trials (RCTs) of acutely ill adult patients randomized to receive CCUS as compared with no CCUS to guide fluid management. DATA EXTRACTION: Reviewers screened abstracts, full texts, and extracted data independently and in duplicate. We pooled data using a random-effects model, assessed the risk of bias using the modified Cochrane tool and assessed the certainty of evidence using the Grading Recommendations Assessment, Development, and Evaluation approach. DATA SYNTHESIS: We included 17 RCTs (n = 1765 patients) in this review. Pooled analyses found that the use of CCUS for volume management in acutely ill patients may decrease mortality at the longest reported time period (relative risk [RR], 0.79; 95% CI, 0.67-0.95; low certainty) and decreases the fluid balance up to 72 hours after admission (mean difference [MD], 0.72 L lower; 95% CI, 1.5 L lower to 0.07 L higher; low certainty). CCUS had an uncertain effect on duration of mechanical ventilation (MD, 1.14 d fewer; 95% CI, 3.35 d fewer to 1.07 d more; very low certainty), ICU length of stay (LOS) (MD, 0.01 d fewer; 95% CI, 1.12 d fewer to 1.09 d more; very low certainty), the need for vasopressors (RR, 0.39; 95% CI, 0.10-1.62; very low certainty), acute kidney injury (AKI) (RR, 0.94; 95% CI, 0.32-2.72; very low certainty), and the need for renal replacement therapy (RRT) (RR, 0.79; 95% CI, 0.17-3.66; very low certainty).
conclusionsIn acutely ill adult patients, CCUS for the use of targeted volume management may reduce mortality and fluid balance up to 72 hours after admission. CCUS has an uncertain effect on ICU LOS, duration of mechanical ventilation, duration of vasopressor use, AKI, and the need for RRT. However, this evidence is limited by imprecision and indirectness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.