Evidence map›Paper›PMID 40366270›Full record

ArticleAlimentary pharmacology & therapeutics2025

Research Communication: Real-World Effectiveness of Budesonide Orodispersible Tablets for Eosinophilic Oesophagitis: The Importance of Patience and Education.

Sarah Taylor, Emily Barwick, Varan Perananthan, Nikita Parkash, Sarah Lucas, Ayushi Chauhan, Catherine Yu, Katrina Tan, Gloria Sepe, Mani Suleiman and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Alimentary pharmacology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sarah TaylorDepartment of Gastroenterology, Northern Health, Epping, Victoria, Australia.ORCID https://orcid.org/0009-0001-7985-4804
Emily BarwickThe University of Melbourne, Melbourne, Victoria, Australia.
Varan PerananthanDepartment of Gastroenterology, Alfred Health, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-4087-4998
Nikita ParkashDepartment of Gastroenterology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Sarah LucasDepartment of Gastroenterology, Northern Health, Epping, Victoria, Australia.ORCID https://orcid.org/0000-0002-4290-6631
Ayushi ChauhanDepartment of Gastroenterology, Northern Health, Epping, Victoria, Australia.ORCID https://orcid.org/0000-0002-2266-4903
Catherine YuDepartment of Gastroenterology, Northern Health, Epping, Victoria, Australia.ORCID https://orcid.org/0009-0001-0424-602X
Katrina TanDepartment of Gastroenterology, Northern Health, Epping, Victoria, Australia.
Gloria SepeDepartment of Gastroenterology, Northern Health, Epping, Victoria, Australia.
Mani SuleimanResearch Development and Governance Unit, Northern Health, Epping, Victoria, Australia.
Diana LewisDepartment of Gastroenterology, Northern Health, Epping, Victoria, Australia.
Chamara BasnayakeThe University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-6103-769X
Hamish PhilpottDepartment of Gastroenterology, Northern Adelaide Local Health Network (NALHN), Adelaide, Australia.
Sanjay NandurkarDepartment of Gastroenterology, Eastern Health, Box Hill, Victoria, Australia.
Rebecca BurgellDepartment of Gastroenterology, Alfred Health, Melbourne, Victoria, Australia.
Mayur GargDepartment of Gastroenterology, Northern Health, Epping, Victoria, Australia.ORCID https://orcid.org/0000-0002-9149-3589

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Budesonide orodispersible tablets (BOT) have been shown to be efficacious for eosinophilic oesophagitis (EoE) in clinical trials. This study evaluated the real-world effectiveness of BOT in a retrospective cohort of 94 patients across six tertiary centres. 61% of patients achieved histological remission and 39% clinicohistological remission following induction therapy. Adverse events were reported by 16% of patients and 17% were noted to have incorrect technique of administration. BOT was demonstrated to have lower rates of clinicohistological remission in real-world practice than reported in clinical trials, largely due to incorrect technique and cessation due to adverse events.

Indexed as

Anti-Inflammatory AgentsBudesonideEosinophilic EsophagitisAdministration, OralAdolescentAdultAgedFemaleHumansMaleMiddle AgedPatient Education as TopicRetrospective StudiesTabletsTreatment OutcomeYoung AdultAnti-Inflammatory AgentsBudesonideTablets

Identifiers

PMID40366270
PMCPMC12203141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.