Evidence map›Paper›PMID 40366260›Full record

ReviewRadiology. Artificial intelligence2025

Privacy-preserving Federated Learning and Uncertainty Quantification in Medical Imaging.

Nikolas Koutsoubis, Asim Waqas, Yasin Yilmaz, Ravi P Ramachandran, Matthew B Schabath, Ghulam Rasool

Abstract readReview
In one paragraph

Review in Radiology. Artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nikolas KoutsoubisDepartment of Machine Learning, Moffitt Cancer Center, Tampa, Fla.ORCID 0000-0001-6195-9360
Asim WaqasDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Fla.ORCID 0000-0002-6834-4710
Yasin YilmazDepartment of Electrical Engineering, University of South Florida, 4202 E Fowler Ave, Tampa, FL 33620-9951.
Ravi P RamachandranDepartment of Electrical and Computer Engineering, Rowan University, Glassboro, NJ.ORCID 0000-0003-0011-4561
Matthew B SchabathDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Fla.
Ghulam RasoolDepartment of Machine Learning, Moffitt Cancer Center, Tampa, Fla.ORCID 0000-0001-8551-0090

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Quantitative Imaging Clinical Validation Center at Moffitt Cancer CenterU01CA200464 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JOHN J HEINE, Matthew B. Schabath · 2016 to 2026
$9.2M
Radiomics of NSCLCU01CA143062 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GILLIES, ROBERT J., SCHABATH, MATTHEW B. · 2010 to 2020
$5.7M
NCI NIH HHS P30 CA076292NCI NIH HHS U01 CA143062NCI NIH HHS U01 CA200464
6 · The paper itself

Abstract

Artificial intelligence (AI) has demonstrated strong potential in automating medical imaging tasks, with potential applications across disease diagnosis, prognosis, treatment planning, and posttreatment surveillance. However, privacy concerns surrounding patient data remain a major barrier to the widespread adoption of AI in clinical practice, because large and diverse training datasets are essential for developing accurate, robust, and generalizable AI models. Federated learning offers a privacy-preserving solution by enabling collaborative model training across institutions without sharing sensitive data. Instead, model parameters, such as model weights, are exchanged between participating sites. Despite its potential, federated learning is still in its early stages of development and faces several challenges. Notably, sensitive information can still be inferred from the shared model parameters. Additionally, postdeployment data distribution shifts can degrade model performance, making uncertainty quantification essential. In federated learning, this task is particularly challenging due to data heterogeneity across participating sites. This review provides a comprehensive overview of federated learning, privacy-preserving federated learning, and uncertainty quantification in federated learning. Key limitations in current methodologies are identified, and future research directions are proposed to enhance data privacy and trustworthiness in medical imaging applications.

Indexed as

Artificial IntelligenceConfidentialityDiagnostic ImagingMachine LearningPrivacyFederated LearningHumansUncertaintyNeural NetworksPerceptionRadiology-Pathology IntegrationSupervised Learning

Identifiers

PMID40366260
PMCPMC12319697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.