ArticlePlant, cell & environment2025
A Holistic Investigation of Arabidopsis Proteomes Altered in Chloroplast Biogenesis and Retrograde Signalling Identifies PsbO as a Key Regulator of Chloroplast Quality Control.
Article in Plant, cell & environment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- HPlant, cell & environment · 2026Article
- A red/blue optoswitch for temporal control of chloroplast transcription and biogenesis in Arabidopsis.Nature communications · 2026Article
- Proteostasis and protein quality control in chloroplasts: mechanisms and novel insights related to protein mislocalization.Journal of experimental botany · 2025Review
- A Mg-Chelatase Subunit I Missense Mutant in Barley Exhibits a Cold-Sensitive Phenotype Under Field Conditions.Physiologia plantarumArticle
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Authors and funding
15 authors.
Funding
Abstract
Communication between the diverse compartments of plant cells relies on an intricate network of molecular interactions that orchestrate organellar development and adaptation to environmental conditions. Plastid-to-nucleus signalling pathways play a key role in relaying information from developing, mature, and damaged or disintegrating chloroplasts to the nucleus, which serves to coordinate gene expression between the two genomes. To shed light on these mechanisms, we performed a comprehensive analysis of the response of the Arabidopsis thaliana proteomes to perturbation of chloroplast biogenesis by the antibiotic lincomycin (Lin) in the absence of GENOMES UNCOUPLED 1 (GUN1), a key player in plastid-to-nucleus signalling. The topological analysis of protein-protein interactions (PPIs) and co-expression networks enabled the identification of protein hubs in each genotype and condition tested, and highlighted whole-cell adaptive responses to the disruption of chloroplast biogenesis. Our findings reveal a novel role for PsbO, a subunit of the oxygen-evolving complex (OEC), which behaves as an atypical photosynthetic protein upon inhibition of plastid protein synthesis. Notably, and unlike all other subunits of the thylakoid electron transport chain, PsbO accumulates in non-photosynthetic plastids, and is crucial for the breakdown of damaged chloroplasts.
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Registered trials
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