Evidence map›Paper›PMID 40366175›Full record

ArticleJournal of virology2025

Endothelial cell-released mitochondrial DNA promotes B cell differentiation and virus replication during severe fever with thrombocytopenia syndrome virus infection.

Yun-Fa Zhang, Ning Cui, Tong Yang, Jin-Xia Wang, Jia-Hao Chen, Xin Yang, Yong-Xiang Wu, Li-Fen Hu, Xiao-Ai Zhang, Qing-Bin Lu and 3 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yun-Fa Zhang *State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.ORCID 0009-0005-1980-1953
Ning Cui *The 154th Hospital, China RongTong Medical Healthcare Group Co.Ltd, Xinyang, China.
Tong Yang *State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
Jin-Xia Wang *State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
Jia-Hao ChenState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
Xin YangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
Yong-Xiang WuState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
Li-Fen HuDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xiao-Ai ZhangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
Qing-Bin LuDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China.
Xin SuCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.ORCID 0000-0002-6629-9856
Hao LiState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.ORCID 0000-0002-6280-267X
Wei LiuState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.ORCID 0009-0001-6937-2430

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease acquired through tick bites. We have previously demonstrated the correlation between SFTSV-induced mitochondrial dysfunction and inflammation induction, disease progression, and fatal outcome. In the current study, our clinical observation study establishes a strong correlation between elevated levels of circulating cell-free mtDNA and poor prognosis.

Indexed as

B-LymphocytesCell DifferentiationDNA, MitochondrialEndothelial CellsPhlebovirusSevere Fever with Thrombocytopenia SyndromeVirus ReplicationAnimalsFemaleHumansLymphocyte ActivationMaleMitochondriaToll-Like Receptor 9DNA, MitochondrialTLR9 protein, humanToll-Like Receptor 9B cellendothelial cellmtDNASFTSTLR9

Identifiers

PMID40366175
PMCPMC12172443

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.