Evidence map›Paper›PMID 40366144›Full record

ArticlemBio2025

Persistent articular infection and host reactive response contribute to

Jerome S Harms, Michael Lasarev, Thomas Warner, Sergio Costa Oliveira, Judith A Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jerome S HarmsDepartments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Michael LasarevDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Thomas WarnerDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sergio Costa OliveiraDepartamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Judith A SmithDepartments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-4158-8253

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Brucella survival strategy requires endoplasmic reticulum restructuring and interferes with innate immunityR01AI116453 · NIAID · FOUNDATION FOR RESEARCH DEVELOPMENT · PI BARBER, GLEN N, OLIVEIRA, SERGIO C · 2016 to 2025
$1.4M
UW SPECT/CT AcquisitionS10OD028670 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI WEICHERT, JAMEY P · 2020 to 2020
$598k
UPR determinants of Brucella virulenceR21AI146375 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SMITH, JUDITH ANNE · 2021 to 2022
$428k
NCI NIH HHS P30 CA014520NIAID NIH HHS R01 AI116453NIAID NIH HHS R21 AI146375NIH HHS 2R01AI116453-06NIH HHS R21AI146375-01A1NIH HHS S10 OD028670
6 · The paper itself

Abstract

Brucellosis, one of the most prevalent zoonotic diseases worldwide, often results in osteoarticular complications including large joint and axial arthritis mimicking spondyloarthritis. To model this chronic manifestation, we infected autoimmunity-prone SKG mice containing a mutation in the T cell adaptor ZAP-70 with

Indexed as

BrucellaBrucellosisPersistent InfectionSpondylarthritisAnimalsBrucella abortusBrucella melitensisDisease Models, AnimalFemaleMaleMiceBrucellamouse modelspondyloarthritis

Identifiers

PMID40366144
PMCPMC12153262

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.