ArticleJournal of acquired immune deficiency syndromes (1999)2025
Association between changes in script renewal periods and HIV viral non-suppression: a cohort study of a South African private-sector HIV program.
Article in Journal of acquired immune deficiency syndromes (1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Estimates and predictors of HIV viral non-suppression in South African adults on antiretroviral treatment.Journal of the International AIDS Society · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionEvidence is needed to inform differentiated service delivery models for people with HIV (PWH). During the COVID-19 pandemic, South Africa temporarily changed the validity of repeat prescriptions for ART from 6 to 12 months. We evaluated the association between these changes and HIV viral non-suppression in the private health sector.
methodsWe analysed routine claims data from a large private-sector HIV management programme. PWH aged >15 years from 4 months after first ART evidence were included. We conducted an interrupted time-series analysis comparing trends in the proportions of PWH with viral non-suppression (viral load ≥50 copies/mL) during three periods: January 1, 2019 to April 23, 2020 (conventional 6-monthly script renewal); April 24, 2020 to September 25, 2021 (12-monthly renewal); and September 26, 2021 to November 30, 2022 (6-monthly renewal re-instated). We used weighting to maintain the age, sex, ART regimen and medical scheme distributions of our study population over time.
resultsMonthly odds of viral non-suppression initially decreased by 4% per annum (adjusted odds ratio (aOR) 0.96, 95% confidence interval (CI) 0.93-0.99). During 12-monthly renewal, there were steeper declines of 11% per annum (aOR 0.89, 95% CI 0.87-0.91). After 6-monthly renewal was re-introduced, viral non-suppression instead increased by 6% per annum (aOR 1.06 95% CI 1.03-1.09). Changes in slopes were significant (p-values <0.001).
conclusionMeasures implemented during COVID-19 to ensure continued access to chronic medication provided unique evidence for models involving less frequent clinical visits. Extending prescription renewal periods was not associated with worse virologic outcomes among privately-insured PWH.
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Registered trials
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