Evidence map›Paper›PMID 40365998›Full record

ArticleEnvironmental science & technology2025

Exposure to Legacy Per- and Polyfluoroalkyl Substances from Diet and Drinking Water in California Adults, 2018-2020.

Emily H Pennoyer, Toki Fillman, Wendy Heiger-Bernays, Kathleen R Attfield, Hyoung-Gee Baek, Songmei Gao, Sabrina Smith, June-Soo Park, Nerissa Wu, Thomas F Webster

Abstract read
In one paragraph

Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The Impact of Forever Chemicals on Protein Structure and Function.International journal of molecular sciences · 2026
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emily H PennoyerBoston University School of Public Health, 715 Albany St., Boston, Massachusetts 02118, United States.ORCID 0000-0002-5181-4851
Toki FillmanCalifornia Department of Public Health, 850 Marina Bay Pkwy., Richmond, California 94804, United States.
Wendy Heiger-BernaysBoston University School of Public Health, 715 Albany St., Boston, Massachusetts 02118, United States.ORCID 0000-0002-0091-9629
Kathleen R AttfieldCalifornia Department of Public Health, 850 Marina Bay Pkwy., Richmond, California 94804, United States.
Hyoung-Gee BaekCalifornia Department of Toxic Substances Control, 700 Heinz Ave., Berkeley, California 94710, United States.
Songmei GaoCalifornia Department of Toxic Substances Control, 700 Heinz Ave., Berkeley, California 94710, United States.
Sabrina SmithCalifornia Department of Toxic Substances Control, 700 Heinz Ave., Berkeley, California 94710, United States.
June-Soo ParkCalifornia Department of Toxic Substances Control, 700 Heinz Ave., Berkeley, California 94710, United States.
Nerissa WuCalifornia Department of Public Health, 850 Marina Bay Pkwy., Richmond, California 94804, United States.ORCID 0000-0001-6680-9900
Thomas F WebsterBoston University School of Public Health, 715 Albany St., Boston, Massachusetts 02118, United States.ORCID 0000-0003-4896-9323

Funding

NCEH CDC HHS U88 EH001148
6 · The paper itself

Abstract

People are exposed to per- and polyfluoroalkyl substances (PFAS) through multiple sources, with diet historically considered a major source in general populations. This study characterized legacy PFAS in serum from 700 California adults and examined contributions from diet and drinking water. We applied robust regression to estimate associations between nontransformed serum PFAS concentrations, self-reported food consumption, and drinking water PFAS concentrations measured under the USEPA's third Unregulated Contaminant Monitoring Rule (2013-2015). Detectable drinking water concentrations were associated with increased serum perfluorooctanoic acid (PFOA) (0.26 ng/mL; 95% CI: 0.077, 0.43), perfluorohexanesulfonic acid (PFHxS) (0.64 ng/mL; 95% CI: 0.058, 1.23), and perfluorooctanesulfonic acid (PFOS) (0.39 ng/mL; 95% CI: -0.76, 0.86). Seafood consumption was associated with increased perfluorononanoic acid (PFNA) (0.013 ng/mL; 95% CI: 0.0058, 0.021), perfluorodecanoic acid (PFDeA) (0.0059 ng/mL; 95% CI: 0.0026, 0.0092), and perfluoroundecanoic acid (PFUnDA) (0.010 ng/mL; 95% CI: 0.0054, 0.015), while eggs were associated with increased PFDeA (0.0035 ng/mL; 95% CI: 0.00010, 0.0069) and PFNA (0.0073 ng/mL; 95% CI: 0.00017, 0.014). Findings could indicate that dietary contributions may be less than those in earlier studies conducted in other populations, possibly due to shifts in PFAS production over the past 20 years, and that drinking water remains an important source of exposure to PFOA and PFHxS in this population.

Indexed as

DietDrinking WaterEnvironmental ExposureFluorocarbonsAdultCaliforniaCaprylatesEnvironmental MonitoringFemaleHumansMaleMiddle AgedWater Pollutants, ChemicalCaprylatesDrinking WaterFluorocarbonsWater Pollutants, Chemicalbiomonitoringdietdrinking waterexposurePFAS

Identifiers

PMID40365998
PMCPMC12120991

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.