SynthesisJournal of hepato-biliary-pancreatic sciences2025
Efficacy and Safety of Surgical Treatment Among Older Adult Patients (80 Years) With Pancreatic Cancer: A Systematic Review and Meta-Analysis.
Synthesis in Journal of hepato-biliary-pancreatic sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Laboratory frailty index in pancreaticoduodenectomy: short-term safety and long-term prognosis.Surgery today · 2026Article
- Achievement of the Ideal Outcome After Pancreatectomy for Pancreatic Ductal Adenocarcinoma Is Associated With Earlier Initiation and Higher Completion Rates of Adjuvant Chemotherapy and Improved Long-Term Survival.Annals of gastroenterological surgery · 2026Article
- Neoadjuvant and adjuvant treatment for pancreatic ductal adenocarcinoma in patients over 80 years old based on a nationwide clinical database.Journal of gastroenterology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith rapid population aging, the number of older adult patients presenting with pancreatic cancer is increasing. This meta-analysis aimed to clarify the efficacy and safety of surgical interventions for pancreatic cancer among older adult patients.
methodsLiterature published in PubMed, Cochrane Library, and ICHUSHI databases until January 2024 was systematically searched. Comparative studies reporting outcomes of pancreatic cancer resection among patients aged 80 years or older were included in the analysis. Fifteen retrospective studies involving 22 647 patients were included in the meta-analysis: 2930 patients aged 80 years or older who underwent pancreatic resection, 2059 patients aged 80 years or older treated with chemotherapy, and 17 658 patients under 80 years old.
resultsSurgical treatment had a higher two-year survival rate than chemotherapy among patients with pancreatic cancer aged 80 years or older. These patients experienced similar morbidity, higher mortality, and lower three-year survival rates than those younger than 80 years.
conclusionsSurgical treatment for pancreatic cancer improves survival rates even among patients aged 80 years or older; however, these patients may have a lower chance of recovering from complications. Patients should be informed of these objective findings to ensure shared decision-making regarding the best treatment strategy.
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