ArticleCNS neuroscience & therapeutics2025
Multidimensional Assessment of Psychiatric Adverse Events Related to Proton Pump Inhibitors: A Real-World, Pharmacovigilance Study.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mendel randomization confirmed gastroesophageal reflux disease may increase the risk of mental disorders.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Article
- Medication-safety burden of omeprazole in psychiatric inpatients: A retrospective cross-sectional study.The Journal of international medical research · 2026Article
- Article
- Gastric Proton Pumpopathy Associated with Protein Sorting Machinery: A Narrative Review.Clinical and experimental gastroenterology · 2026Review
- Proton pump inhibitor use and risk of depression among Sudanese adults: a cross-sectional community-based study.Frontiers in psychiatry · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLimited research has been conducted on the association between proton pump inhibitors (PPIs) use and psychiatric adverse events (AEs), leaving the understanding of PPIs-related psychiatric AEs in real-world settings unclear.
objectivesWe aim to identify psychiatric AEs highly relevant to five commonly prescribed PPIs and to delve into the clinical characteristics of the population experiencing psychiatric AEs, as well as the time-to-onset pattern of the reported AEs.
methodsWe performed disproportionality analysis to evaluate the PPI-related psychiatric AEs risk signal using data from the FDA adverse event reporting system. Linkage disequilibrium score regression, high-definition likelihood, and Bidirectional MR analyses were employed to evaluate genetic correlations and causality for the pairwise traits between indications for PPI therapy and three common psychiatric disorders.
resultsPsychiatric AEs were reported in 12.83% of all AE reports on PPIs. Disproportionality analysis identified multiple PPI-related psychiatric AE risk signals such as depressive disorder, bipolar disorder, and sleep disorder, with Omeprazole exhibiting the highest number of positive signals and cases (N = 386) and Rabeprazole the fewest (N = 28). Notably, we detected positive signals for suicide or self-injury-related AEs in three types of PPIs. Significant genetic correlations were revealed in peptic ulcer with major depressive disorder, peptic ulcer with schizophrenia, and gastroesophageal reflux disease (GERD) with major depressive disorder. Bidirectional MR analyses identified significant causal relationships between MDD and peptic ulcer, and a potential bidirectional causal association between GERD and MDD.
conclusionsPPI-related psychiatric AEs may represent a non-negligible portion of overall PPI-related AEs. It is recommended to monitor and evaluate the safety of long-term PPI use in relation to psychiatric AEs.
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