Evidence map›Paper›PMID 40365715›Full record

ArticleCNS neuroscience & therapeutics2025

Hydrogen Sulfide Modulates Microglial Polarization and Remodels the Injury Microenvironment to Promote Functional Recovery After Spinal Cord Injury.

Yu Wang, Xinyi Jia, Yuqi Zhang, Haibin Shi, Yuhui Sun, Yaobo Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Sappanone A Promotes Motor Function Recovery in Spinal Cord Injury Mice by Inhibiting Microglial M1 Polarization via Activation of the Keap1/Nrf2 Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu WangJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Institute of Neuroscience, Soochow University, Departments of Rehabilitation Medicine and Neurology, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Xinyi JiaJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Institute of Neuroscience, Soochow University, Departments of Rehabilitation Medicine and Neurology, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Yuqi ZhangState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, and Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Haibin ShiState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, and Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Yuhui SunJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Institute of Neuroscience, Soochow University, Departments of Rehabilitation Medicine and Neurology, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Yaobo LiuJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Institute of Neuroscience, Soochow University, Departments of Rehabilitation Medicine and Neurology, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0000-0002-7663-5649

Funding

a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe Key Research and Development Plan of Jiangsu Province BE2023701,BE2018654the National Key Research and Development Program of China 2023YFC2306502,2023YFC2412502the National Natural Sciences Foundation of China 82171376,81971164,81771330
6 · The paper itself

Abstract

aimsSpinal cord injury (SCI) disrupts tissue homeostasis, leading to persistent neuroinflammation and scar formation that severely impedes functional recovery. Current therapeutic approaches are insufficient to address these challenges. In this study, we investigated whether exogenous hydrogen sulfide (H

methodsT10 crush SCI was induced in mice, followed by daily intraperitoneal administration of the H

resultsADT-based H

conclusionH

Indexed as

Cell PolarityCellular MicroenvironmentHydrogen SulfideMicrogliaRecovery of FunctionSpinal Cord InjuriesAnimalsFemaleMaleMiceMice, Inbred C57BLHydrogen Sulfidefunctional recoveryhydrogen sulfideneuroinflammationscar formationspinal cord injury

Identifiers

PMID40365715
PMCPMC12076064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.