ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Lipid Droplet-Derived Biomimetic Nanocarriers for the Enhancement of Porcine Intermuscular Fat Content.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Integrated ATAC-Seq and RNA-Seq Reveal Candidate Regulatory Genes and Chromatin Accessibility Associated with Intramuscular Fat Deposition: An Animal Trial in Hezuo Pigs.Animals : an open access journal from MDPI · 2026Article
- HSV-1-Driven Lipid Metabolic Reprogramming and Lipid Droplet Accumulation in Macrophages Impair Antiviral Immunity.Investigative ophthalmology & visual science · 2026Article
- Lipid droplets-mediated delivery of curcumin for targeted mitochondrial photodynamic therapy.International journal of pharmaceutics: X · 2026Article
- Article
- Lipid Droplet-Derived Biomimetic Nanocarriers for the Enhancement of Porcine Intermuscular Fat Content.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Intramuscular fat (IMF) content is a critical factor influencing the quality and palatability of pork. However, established breeding and nutritional methods lead to systemic fat deposition. The efficient and specific methods to increase IMF content in livestock remain a challenge. In this study, Lipid droplets (LDs), an organelle in cells, are shown to be a controllable and biocompatible carrier that can be used to increase IMF content. This study demonstrated that isolated LDs stimulate lipid synthesis by encapsulating Oleic Acid (OA), a PPARγ ligand. Importantly, artificial LDs (aLDs) can effectively substitute isolated LDs. In vivo, investigations showed that OA-loading aLDs significantly increased the expression of lipid synthases such as DGAT2 and FASN through activation of PPARγ, a key pathway for lipid synthesis. Furthermore, the IMF content on the injected side is increased up to 35% with minimal side effects. The development of OA-aLDs promotes IMF deposition and demonstrates the significant potential of aLDs as drug carriers. The exploration of LDs-based carriers provides a new theoretical basis for their application in the medical field.
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Registered trials
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