Evidence map›Paper›PMID 40365493›Full record

ArticleFrontiers in medicine2025

Impact of vitamin C deficiency on imaging patterns and ventilatory function in pulmonary tuberculosis.

Ramona Cioboata, Mara Amalia Balteanu, Ovidiu Mircea Zlatian, Silviu Gabriel Vlasceanu, Mircea Vasile Popescu Driga, Denisa Maria Mitroi, Oana Maria Catana, Cezar Ionut Buciu, Georgiana Camen, Adina Andreea Mirea

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ramona Cioboata *Department of Pneumology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Mara Amalia Balteanu *Department of Pulmonology, Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania.
Ovidiu Mircea ZlatianDepartment of Microbiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Silviu Gabriel VlasceanuDepartment of Physiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Mircea Vasile Popescu DrigaDepartment of Microbiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Denisa Maria MitroiDoctoral School, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Oana Maria CatanaDoctoral School, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Cezar Ionut BuciuDoctoral School, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Georgiana CamenDepartment of Radiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Adina Andreea MireaDepartment of Oral-Dental Prevention, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies have shown that vitamin C is essential for the immune response to tuberculosis (TB), and that its deficiency may elevate the risk of TB and related complications. This prospective study investigated the association between disease severity, imaging findings and vitamin C levels. Methods: This study enrolled 109 patients with confirmed pulmonary tuberculosis based on Results: At baseline, patients in the low vitamin C group showed significantly higher bacillar loads, with 86.00% presenting loads of 2+ or higher compared with 59.32% in the normal group ( Conclusion: Vitamin C deficiency is correlated with increased disease severity, delayed bacterial clearance, and persistent pulmonary damage in patients with tuberculosis. Vitamin C supplementation can enhance treatment outcomes in tuberculosis therapy.

Indexed as

chest imagingCT scanpulmonary tuberculosisspirometryvitamin C

Identifiers

PMID40365493
PMCPMC12069067

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.