Evidence map›Paper›PMID 40365421›Full record

ArticleACS medicinal chemistry letters2025

Design, Synthesis, and Evaluation of Sodium Channel Blockers with Anti-invasive Activities in Medullary Thyroid Cancer.

Piyasuda Pukkanasut, Shilpa Dutta, Jason Whitt, Parvathy Babu, Osbaldo Lopez-Charcas, Tonantzin Guadalupe Anguheven-Ledezma, Juan Carlos Gomora, Renata Jaskula-Sztul, Sadanandan E Velu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Piyasuda PukkanasutDepartment of Chemistry, Department of Surgery, and O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Shilpa DuttaDepartment of Chemistry, Department of Surgery, and O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Jason WhittDepartment of Chemistry, Department of Surgery, and O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Parvathy BabuDepartment of Chemistry, Department of Surgery, and O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Osbaldo Lopez-CharcasDepartamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.ORCID https://orcid.org/0000-0002-5080-8310
Tonantzin Guadalupe Anguheven-LedezmaDepartamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.ORCID https://orcid.org/0009-0005-8029-6167
Juan Carlos GomoraDepartamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.
Renata Jaskula-SztulDepartment of Chemistry, Department of Surgery, and O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Sadanandan E VeluDepartment of Chemistry, Department of Surgery, and O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.ORCID https://orcid.org/0000-0002-0342-2378

Funding

Microbial Biofilms as Regulators of Amphetamine Use DisordersR21DA059844 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARTER, ANGELA MICHELLE, VELU, SADANANDAN E. · 2024 to 2025
$408k
NIDA NIH HHS R21 DA059844
6 · The paper itself

Abstract

This letter describes the structure-activity relationship studies of a voltage-gated sodium channel (VGSC) blocker

Identifiers

PMID40365421
PMCPMC12067137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.