ArticleSkin health and disease2025
The role of lipid metabolism in acne risk: integrating blood metabolite and genetic insights.
Article in Skin health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Lipid Metabolism, Body Composition, and Diet in Acne Vulgaris: A Narrative Review.Metabolites · 2026Review
- Exposome involvement in the development of acne vulgaris.Frontiers in immunology · 2026Review
- Specialized Pro-Resolving Lipid Mediators and Dietary Omega-3/6 Fatty Acids in Selected Inflammatory Skin Diseases: A Systematic Review.Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acne vulgaris is a chronic inflammatory skin condition that significantly impacts an individual's quality of life, affecting social interactions, self-esteem and body image. It primarily targets the pilosebaceous unit, where inflammation occurs. Lipid metabolism is crucial in maintaining the skin barrier and modulating inflammatory responses, with specific fatty acids, such as ω-3 and sphingomyelin acid, playing key roles. Previous studies have highlighted associations between specific dietary habits and acne, yet the precise relationship between lipid profiles, particular fatty acids, dietary patterns and acne, remains inadequately understood. This gap in knowledge necessitates a deeper investigation into the mechanisms linking lipid metabolism with acne risk. Objectives: To investigate the causal association between acne risk and 143 dietary habits alongside 229 blood metabolite markers, focusing on lipid metabolism. Methods: Using a Mendelian randomization (MR) framework, we leveraged summary statistics data from genome-wide association studies to explore the associations between blood lipid metabolites, dietary factors and acne risk. We used statistical correction methods, including Bonferroni and false discovery rate (FDR) adjustments, to identify robust significant associations. Results: Our MR analysis identified 10 lipid metabolites significantly associated with acne risk. After applying Bonferroni and FDR corrections, we pinpointed 10 and 27 serum indices or metabolites, respectively, as significantly linked to acne risk. The most prominent protective factors against acne included a higher ratio of polyunsaturated fatty acids to monounsaturated fatty acids (MUFAs) [odds ratio (OR) 0.73, 95% confidence interval (CI) 0.65-0.83, Conclusion: Our study highlights the causal relationship between lipid markers and acne. Specifically, we identified 10 lipid traits, including monounsaturated and polyunsaturated fatty acids, ω-3/ω-6 and sphingomyelins, that influence acne development. These findings align with existing evidence on the role of lipids in skin health and comedogenesis. Further research is warranted to explore underlying mechanisms and assess the impact of dietary fats on acne, as well as to evaluate targeted interventions for diverse patient subgroups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.