Evidence map›Paper›PMID 40365231›Full record

ArticleFrontiers in endocrinology2025

Oocytes with aggregates of smooth endoplasmic reticulum may not affect reproductive outcomes in split IVF-ICSI insemination: a retrospective study.

Yejuan Li, Jiajia Hu, Hui Lu, Zhiyong Lu, Jingjing Zhong, Lisen Shi

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yejuan LiReproductive Medical Center, Hainan Women and Children's Medical Center, Haikou, China.
Jiajia HuReproductive Medical Center, Hainan Women and Children's Medical Center, Haikou, China.
Hui LuReproductive Medical Center, Hainan Women and Children's Medical Center, Haikou, China.
Zhiyong LuReproductive Medical Center, Hainan Women and Children's Medical Center, Haikou, China.
Jingjing ZhongReproductive Medical Center, Hainan Women and Children's Medical Center, Haikou, China.
Lisen ShiMedical Genetics and Prenatal Diagnosis, Haikou Maternal and Child Health Hospital, Haikou, Hainan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the impact of smooth endoplasmic reticulum aggregates (SERa) in oocytes on embryological outcomes and clinical and neonatal outcomes during split IVF-ICSI cycles. Methods: A retrospective analysis was conducted using clinical data from January 2020 to December 2023 at the Reproductive Medicine Center of Hainan Women and Children's Medical Center. Patients were divided into SERa+ and SERa- cycles based on the visibility of SERa after the removal of cumulus cells. Basic patient characteristics, embryological outcomes, clinical and neonatal outcomes were compared between the two groups. Results: Compared to the SERa- cycles, the SERa+ cycles showed significantly higher levels of E Conclusion: The occurrence of SERa in split IVF-ICSI cycles may be associated with increased E

Indexed as

Endoplasmic Reticulum, SmoothFertilization in VitroOocytesSperm Injections, IntracytoplasmicAdultFemaleHumansPregnancyPregnancy OutcomePregnancy RateRetrospective Studiesclinical and neonatal outcomesembryological outcomesoocyteSERasplit IVF-ICSI

Identifiers

PMID40365231
PMCPMC12069068

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.