ArticleFrontiers in physiology2025
Evaluating the effects of pharmaceutical pollutants on common carp (
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The release of pharmaceutical chemicals into aquatic environments has emerged as a significant ecological concern, originating from agricultural runoff, sewage effluents, and improper disposal of medications. Methods: This study investigates the impacts of four common pharmaceuticals (bromazepam, naproxen, metoprolol, and sotalol) on common carp ( Results: Neurological assessments showed significant reductions in acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities, and nitric oxide (NO) levels, indicating potential disruptions in neurotransmission and enzyme function. Immunological analysis revealed elevated levels of pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6), suggesting an inflammatory response. Histopathological examinations identified tissue alterations in the liver, kidney which correlated with the observed biochemical and immune responses. Discussion: These findings highlight the adverse effects of pharmaceutical contaminants on aquatic species, emphasizing the necessity for comprehensive environmental risk assessments and strategies to mitigate their impact. This study enhances the understanding of pharmaceutical pollutants' ecological effects, informing policy and conservation efforts to protect aquatic ecosystems.
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