ReviewCureus2025
Cost-Effectiveness of Carbon Ion Radiotherapy in Oncology: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Methods and evidence in economic evaluations of modern radiotherapy: a systematic mapping review protocol.BMJ open · 2026Article
- Clinical White Paper From the "Hadrontherapy for Life" Symposium-Clinical Expansion of Carbon Ion Facilities Worldwide.International journal of particle therapy · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon ion radiotherapy (CIRT) offers significant physical and biological advantages compared to conventional photon or proton therapies, particularly in the treatment of chemoradio-resistant tumors. However, the widespread adoption of CIRT has been limited due to high treatment and infrastructure costs. This systematic review evaluated the cost-effectiveness of CIRT relative to other treatment modalities across different cancer types. A structured literature search identified five eligible studies encompassing 486 patients with skull base chordoma, locally recurrent rectal cancer, localized hepatocellular carcinoma, and stage I non-small-cell lung cancer. Although CIRT was associated with higher primary treatment costs compared to conventional therapies, it consistently demonstrated favorable cost-effectiveness ratios, with incremental cost-effectiveness ranging from up to $88,663 per additional life-year or quality-adjusted life-year gained. In cases of recurrent tumors, CIRT resulted in lower overall treatment costs than comparator therapies. Additionally, CIRT exhibited a favorable toxicity profile, with minimal severe adverse events reported. These findings suggest that despite higher initial expenditures, CIRT represents a cost-effective and clinically advantageous treatment option across a range of malignancies, warranting broader consideration in oncologic practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.