ReviewCureus2025
Efficacy of Cryotherapy After Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pain Management in Mandibular Molars With Symptomatic Irreversible Pulpitis: Mechanisms, Clinical Efficacy and Current Evidence: A Narrative Review.Pain research & management · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inferior alveolar nerve block (IANB) is routinely employed to achieve pulpal anesthesia during endodontic procedures. Cryotherapy is a well-established method for managing postoperative pain; however, evidence regarding its efficacy in enhancing IANB outcomes remains limited. This systematic review and meta-analysis aimed to evaluate the efficacy of cryotherapy application following IANB in patients with symptomatic irreversible pulpitis. A comprehensive search was conducted in PubMed, Scopus, Web of Science (WOS), and Cochrane Central from inception to February 2025 for randomized controlled trials (RCTs) assessing cryotherapy application after IANB. The primary outcomes included success rates, pain intensity measured using the Visual Analogue Scale (VAS), and anxiety levels assessed by the Dental Anxiety Scale-Revised (DAS-R). Dichotomous data were analyzed using odds ratios (ORs) with 95% confidence intervals (CIs), while continuous data were analyzed using mean differences (MDs) with 95% CIs under a random-effects model. All statistical analyses were performed using STATA version 18MP (www.stata.com). Six RCTs involving 506 patients were included. Ice pack application following IANB significantly improved success rates compared to no cryotherapy (OR: 1.44; 95% CI: 1.04-2.00; p = 0.03), whereas no significant difference was observed with Endo Ice. Cryotherapy also resulted in significantly greater pain reduction intraoperatively and at one hour postoperatively compared to control (MD = -0.83; 95% CI: -1.61 to -0.05; p = 0.04 and MD = -3.08; 95% CI: -5.56 to -0.60; p = 0.01, respectively). In conclusion, cryotherapy application following IANB enhances anesthetic efficacy and reduces pain in patients with irreversible pulpitis. Further high-quality trials with longer follow-up durations are recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.