Evidence map›Paper›PMID 40364837›Full record

ArticleFrontiers in immunology2025

Transcriptional co-regulator OCA-B/Pou2af1 restricts Th2 differentiation.

Erik P Hughes, Asit K Manna, Wenxiang Sun, Sandra M Osburn-Staker, Samuel Aamodt, Kristi J Warren, James E Cox, Dean Tantin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erik P HughesDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Asit K MannaDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Wenxiang SunHuntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, United States.
Sandra M Osburn-StakerDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, United States.
Samuel AamodtDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States.
Kristi J WarrenDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States.
James E CoxDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, United States.
Dean TantinDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.

Funding

Role of Transcription Coactivator OCA-B in Gene Poising and Immunological MemoryR01AI100873 · NIAID · UNIVERSITY OF UTAH · PI TANTIN, DEAN · 2013 to 2022
$3.8M
Targeting OCA-B in multiple sclerosisR01AI162929 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DEAN TANTIN · 2022 to 2026
$2.0M
The Neuroimmunology Training Program at the University of UtahT32NS115664 · NINDS · UNIVERSITY OF UTAH · PI O'CONNELL, RYAN M, WILCOX, KAREN S · 2020 to 2024
$988k
BLRD VA IK2 BX004219NIAID NIH HHS R01 AI100873NIAID NIH HHS R01 AI162929NINDS NIH HHS T32 NS115664
6 · The paper itself

Abstract

Background: Type 2 immunity is initiated through a synergistic response between innate and adaptive immune cells to facilitate host-pathogen defense and wound repair, yet aberrant responses can contribute to chronic inflammation and allergic disease. CD4 Method: We used a proximity labeling system to map proteins associated with the transcriptional co-regulator OCA-B, encoded by Results: We find that OCA-B indirectly associates with GATA3. ChIP-seq analysis reveals coenrichment of Gata3 and the transcription factor Oct1, a partner protein of OCA-B, at genomic locations responsible for the Th2 program including Conclusion: These findings shown that OCA-B helps restrict Th2 function at least in part through communication with GATA3.

Indexed as

Cell DifferentiationTh2 CellsAnimalsCytokinesGATA3 Transcription FactorHumansMiceMice, Inbred C57BLCytokinesGata3 protein, mouseGATA3 Transcription FactorBob1CD4+ T cellsGata3OCA-BPou2af1Th2

Identifiers

PMID40364837
PMCPMC12069319

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.