ArticleCurrent opinion in behavioral sciences2025
Interactions of sex and stress in modulation of ventral tegmental area dopaminergic activity.
Article in Current opinion in behavioral sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Prenatal Methyl Nutrient Availability Shapes Mesolimbic Dopaminergic Circuitry and Systemic Inflammation in Wistar Rat Offspring of Both Sexes.Journal of neurochemistry · 2026Article
- Stress resilience is associated with transcriptional remodeling in the VTA.Cell reports · 2026Article
- Stress resilience is associated with transcriptional remodeling in the VTA.bioRxiv : the preprint server for biology · 2025Article
- Untangling the multifaceted VTA responses to stress.Trends in neurosciences · 2025Review
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Authors and funding
2 authors.
Funding
Abstract
Dopaminergic (DA) neurons of the ventral tegmental area (VTA) have long been studied for their role in reward prediction and goal-directed behaviors. However, appreciation is growing for a complementary role of VTA DA neurons in responding to aversive stimuli and as critical substrates for behavioral sequelae of stressful experiences. As is the case across neuroscience, the majority of our knowledge about VTA DA neurons comes from studies in male subjects. Recent years have seen an increase in inclusion of female subjects and exploration of sex differences. There is now an emerging body of literature showing that although there are minimal basal structural and functional sex differences in VTA DA neurons, experience-dependent changes in these neurons can differ significantly between males and females. Here, we discuss potential implications of sex differences in VTA function and review recent data on sex differences and similarities of DA neurons at baseline and following stress.
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