Evidence map›Paper›PMID 40364778›Full record

ArticleVeterinary dermatology2025

Evaluation of canine epidermis and keratinocytoids (keratinocytic organoids) by transmission electron microscopy.

Clinson C Lui, Dominique J Wiener, Katia R Groch, Lauren W Stranahan, Christina R Heard, Aníbal G Armién

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Clinson C LuiDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0001-6644-2328
Dominique J WienerDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0002-1876-4581
Katia R GrochDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Lauren W StranahanDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Christina R HeardUltrastructural Pathology Unit, California Animal Health & Food Safety Laboratory System, Davis, California, USA.
Aníbal G ArmiénUltrastructural Pathology Unit, California Animal Health & Food Safety Laboratory System, Davis, California, USA.ORCID https://orcid.org/0000-0002-1870-9945

Funding

Comparative Biomedical Research Training for VeterinariansT32OD011083 · OD · TEXAS A&M AGRILIFE RESEARCH · PI ALBERT MULENGA · 2012 to 2026
$4.8M
International Society of Veterinary DermatopathologyNIH HHS T32 OD011083NIH-T32 Institutional Training grant (Ruth L. Kirschstein Institutional National Research Service Award)
6 · The paper itself

Abstract

backgroundSkin disease is a common complaint in veterinary medicine. Current models often use live animals. Epidermal organoids (keratinocytoids) are 3D miniature organs created in culture from single epidermal keratinocytes. These keratinocytoids can be used as an alternative to live animal studies to investigate epidermal structures and skin diseases. HYPOTHESIS/

objectiveThis study's objective was to compare ultrastructural morphological features of canine keratinocytoids to those features of normal epidermis.

resultsSkin and organoids had morphologically similar components, including tight junctions, desmosomes, lamellar bodies and keratin filaments. These structures were similar in both morphology and distribution. Keratinocytes in the organoids had larger and more distinct keratohyalin granules than epidermal keratinocytes and contained small amounts of glycogen. Keratinocytes from the skin showed no glycogen accumulation. CONCLUSIONS AND CLINICAL RELEVANCE: Canine keratinocytoids are a useful model to study canine epidermal disease from a light microscopy and ultrastructural standpoint.

Indexed as

EpidermisKeratinocytesOrganoidsAnimalsDogsKeratinsMicroscopy, Electron, TransmissionKeratinsdesmosomesepidermiskeratinocytelamellar bodiesorganoidultrastructure

Identifiers

PMID40364778
PMCPMC12420878

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.