Evidence map›Paper›PMID 40364747›Full record

Trial reportBJOG : an international journal of obstetrics and gynaecology2025

Impact of Aspirin on Timing of Birth in Pregnancies With Clinical Manifestations of Placental Dysfunction: Evidence From a Multicentre Randomised Clinical Trial.

Ioannis Papastefanou, Yunyu Chen, Long Nguyen-Hoang, Duy-Anh Nguyen, Linh Thuy Dinh, Ritsuko K Pooh, Arihiro Shiozaki, Mingming Zheng, Yali Hu, Yunping Wu and 19 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BJOG : an international journal of obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Ioannis PapastefanouDepartment of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.ORCID https://orcid.org/0000-0002-7969-1435
Yunyu ChenDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.ORCID https://orcid.org/0000-0002-5632-3445
Long Nguyen-HoangDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Duy-Anh NguyenHanoi Obstetrics and Gynecology Hospital, Hanoi, Vietnam.
Linh Thuy DinhHanoi Obstetrics and Gynecology Hospital, Hanoi, Vietnam.
Ritsuko K PoohCRIFM Prenatal Medical Clinic, Osaka, Japan.
Arihiro ShiozakiToyama University Hospital, Toyama, Japan.
Mingming ZhengNanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.
Yali HuNanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.ORCID https://orcid.org/0000-0001-5475-7840
Yunping WuKunming Angel Women and Children's Hospital, Kunming, China.
Aditya KusumaHarapan Kita National Women and Children Hospital, Jakarta, Indonesia.
Piengbulan YapanFaculty of Medicine, Siriraj Hospital, Bangkok, Thailand.
Mahesh A ChoolaniDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Mayumi KanekoShowa University Hospital, Tokyo, Japan.
Suchaya LuewanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Tung-Yao ChangDepartment of Fetal Medicine, Taiji Clinic, Taipei, Taiwan.
Noppadol ChaiyasitKing Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Tongta NanthakomonDepartment of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Yanmin JiangDepartment of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Steven W ShawTaipei Chang Gung Memorial Hospital, Taipei, Taiwan.
Wing Cheong LeungDepartment of Obstetrics and Gynecology, Kwong Wah Hospital, Hong Kong, SAR, China.
Ainaa Syazana MohamadDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.
Angela AguilarUniversity of the Philippines College of Medicine, the Philippine General Hospital, Manila, Philippines.
So Ling LauDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Nikki M W LeeDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Esther Wai Chi TangDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Daljit S SahotaDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.ORCID https://orcid.org/0000-0002-3755-2701
Marc K C ChongThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Liona C PoonDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.

Funding

Astraia GmbHGE HealthcareRevvity IncRoche Diagnosticsthe Faculty of Medicine, the Chinese University of Hong KongThermo Fisher Scientific
6 · The paper itself

Abstract

objectiveTo examine whether aspirin delays gestational age at delivery (GAD) in pregnancies with placental dysfunction (PD) phenotypes (preeclampsia [PE], small-for-gestational-age [SGA], placental abruption and/or stillbirth).

designA secondary analysis of a multicentre stepped-wedge cluster randomised trial.

setting18 maternity/diagnostic units in Asia. POPULATION: Singleton pregnancies examined at 11-13

methodsA model in which the effect of aspirin is to delay the GAD in pregnancies with PD was developed.

main outcome measuresGAD in pregnancies with PD.

resultsAspirin administration was associated with a significant reduction in PD < 32 weeks (adjusted relative risk 0.543, 95% CI: 0.330-0.864), with a trend for an increase of PD ≥ 32 weeks (test for trend, p-value = 0.0018). Similar findings were observed individually for PE, SGA and/or placental abruption. At 24 weeks, the aspirin-induced prolongation of pregnancies with PD was 2.85 weeks (95% CI: 0.44-5.40), and this effect was decreased by -0.19 weeks (95% CI: -0.33 to -0.05) for each week of gestation; therefore, at 28 and 32 weeks' gestation, the aspirin-induced prolongation was 2.09 and 1.33 weeks, respectively.

conclusionsIn this secondary analysis of a cluster randomised trial, women at high risk of PE who are destined to develop a clinical spectrum of PD may benefit from longer pregnancy duration through aspirin administration in early pregnancy. Aspirin may delay the GAD due to PD, particularly benefiting those deliveries that would occur at earlier gestations without aspirin administration.

Indexed as

AspirinPlacenta DiseasesAbruptio PlacentaeAdultFemaleFetal Growth RetardationGestational AgeHumansInfant, NewbornInfant, Small for Gestational AgePre-EclampsiaPregnancyStillbirthAspirinaspirinplacental dysfunctionpre‐eclampsia

Identifiers

PMID40364747
PMCPMC12315083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.