Evidence map›Paper›PMID 40364666›Full record

ArticleJournal of biophotonics2025

Mid-IR Imaging Can Detect Waste Heat Production in the Nematode Caenorhabditis elegans.

Ryan A Merritt, Kegan Heaney, Nuren Shuchi, Kacy L Gordon, Susan R Trammell

Abstract read
In one paragraph

Article in Journal of biophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryan A MerrittDepartment of Biology, UNC Chapel Hill, Chapel Hill, North Carolina, USA.
Kegan HeaneyDepartment of Physics and Optical Science, UNC Charlotte, Charlotte, North Carolina, USA.
Nuren ShuchiDepartment of Physics and Optical Science, UNC Charlotte, Charlotte, North Carolina, USA.
Kacy L GordonDepartment of Biology, UNC Chapel Hill, Chapel Hill, North Carolina, USA.
Susan R TrammellDepartment of Physics and Optical Science, UNC Charlotte, Charlotte, North Carolina, USA.ORCID 0000-0002-4861-3485

Funding

Extreme cell growth in support of stem cell proliferation and niche exitR35GM147704 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kacy Lynn Gordon · 2022 to 2026
$2.1M
NIGMS NIH HHS R35 GM147704NIH HHS
6 · The paper itself

Abstract

Organisms carry out metabolic processes to produce chemical energy, but these biochemical pathways are inherently inefficient, resulting in the loss of energy as heat. This study reports the first characterization of the thermal signature of waste heat production in the ectothermic invertebrate Caenorhabditis elegans using thermal infrared (8-10 μm) imaging. A label-free imaging approach was developed to distinguish the heat output of living versus dead C. elegans by employing a cold object in reflectance mode with a highly reflective imaging substrate to suppress the thermal background. This method reveals a clear, repeatable difference in both the thermal output and cooling rate of living versus dead worms. Fourier Transform Infrared (FT-IR) spectroscopy confirms that the measured temperature differences arise from variations in kinetic temperature rather than differences in thermal emissivity. This novel approach provides a powerful tool for studying the previously inaccessible thermal biology of small ectothermic invertebrates.

Indexed as

Caenorhabditis elegansHot TemperatureInfrared RaysAnimalsSpectroscopy, Fourier Transform InfraredC. elegansimaging of living organismslabel‐free imagingmetabolismmid‐IR imagingthermal imaging

Identifiers

PMID40364666
PMCPMC12245489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.