ArticleNeural regeneration research2026
Neuroinflammation strokes the brain: A double-edged sword in ischemic stroke.
Article in Neural regeneration research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Leptomeningeal Collaterals Constitute an Immune-Responsive Vascular Niche in Ischemic Stroke.Stroke · 2026Article
- Routine C-Reactive Protein on Admission and In-Hospital Outcomes in Acute Ischemic Stroke Patients Treated with Thrombectomy: A Retrospective Single-Center Study.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Neuroinflammation after stroke: initiation, amplification and therapeutic prospects.Journal of translational medicine · 2026Review
- Xuming Zhusan Decoction Attenuates Post-Stroke via Modulating TLR4/MYD88/NF-κB Pathway in Mice.Food science & nutrition · 2026Article
- Prognostic Value of Inflammatory Hematological Indices for In-Hospital Mortality After Stroke.Medicina (Kaunas, Lithuania) · 2026Article
- Modulating Post-Stroke Inflammation with FDA-Approved Immunotherapies: A Literature Review.International journal of molecular sciences · 2026Review
- From anti-inflammation to pro-resolution: a new paradigm for specialized pro-resolving mediators in regulating neuroinflammation and repair after cerebral ischemia-reperfusion.Frontiers in immunology · 2026Review
- Serum Hepatocyte-Derived Fibrinogen-Related Protein-1: A Novel Biomarker for Severity and Clinical Outcome in Acute Ischemic Stroke.Journal of inflammation research · 2026Article
- The spatiotemporal dynamic evolution of post-stroke neuroinflammation: energy metabolism mechanisms of acute response and chronic progression.Frontiers in pharmacology · 2026Review
- Identification of ischemic stroke subtypes defined by inflammation, coagulation, and metabolic profiles.Frontiers in artificial intelligence · 2026Article
- Review
- The Inflammatory Bridge Between Type 2 Diabetes and Neurodegeneration: A Molecular Perspective.International journal of molecular sciences · 2025Review
- Targeting CX3CR1 Signaling Dynamics: A Critical Determinant in the Temporal Regulation of Post-Stroke Neurorepair.Brain sciences · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is a major cause of death and disability worldwide. It is characterized by a highly interconnected and multiphasic neuropathological cascade of events, in which an intense and protracted inflammatory response plays a crucial role in worsening brain injury. Neuroinflammation, a key player in the pathophysiology of stroke, has a dual role. In the acute phase of stroke, neuroinflammation exacerbates brain injury, contributing to neuronal damage and blood-brain barrier disruption. This aspect of neuroinflammation is associated with poor neurological outcomes. Conversely, in the recovery phase following stroke, neuroinflammation facilitates brain repair processes, including neurogenesis, angiogenesis, and synaptic plasticity. The transition of neuroinflammation from a harmful to a reparative role is not well understood. Therefore, this review seeks to explore the mechanisms underlying this transition, with the goal of informing the development of therapeutic interventions that are both time- and context-specific. This review aims to elucidate the complex and dual role of neuroinflammation in stroke, highlighting the main actors, biomarkers of the disease, and potential therapeutic approaches.
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Registered trials
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