SynthesisCurrent medical imaging2025
Malignant Risk Assessment of Cystic-solid Thyroid Nodules Based on Multimodal Ultrasound Features: A Systematic Review and Meta-analysis.
Synthesis in Current medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Effect analysis of percutaneous catheter drainage combined with radiofrequency ablation in the treatment of mixed thyroid nodules.Frontiers in endocrinology · 2025Trial
- Evaluating Consistency and Accuracy of GPT-4 Omni to Analyze Thyroid Ultrasound Features and ACR TR Categories to Aid Report GenerationCurrent medical imaging · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe malignant risk of cystic-solid thyroid nodules may be underestimated in the ultrasound assessment.
objectiveThis systematic review and meta-analysis aimed to evaluate the value of multimodal ultrasound characteristics in the malignant risk assessment of cystic-solid thyroid nodules.
methodsWe conducted a comprehensive search of PubMed, Web of Science, and Cochrane Library databases for studies depicting the ultrasound characteristics of cystic-solid thyroid nodules published prior to October 2023. The Review Manager 5.4 software was utilized to evaluate the ultrasound features suggestive of malignancy and to determine their sensitivity and specificity. Additionally, the Sata 12.0 software was utilized to construct summary receiver operating characteristic curves (SROC), estimate the area under the curve (AUC), and evaluate any potential publication bias.
resultsThis review included 16 studies comprising 5,655 cystic-solid thyroid nodules. Nine ultrasound features were identified as risk factors for tumor malignancy. Among the ultrasound features, microcalcification in the solid portion, heterogeneous hypoenhancement on Contrast-Enhanced Ultrasound (CEUS), and sharp angles in the solid portion exhibited higher malignant predictive value in cystic-solid thyroid nodules, with AUC values of 0.91, 0.84, and 0.81, respectively.
conclusionOur findings indicate that microcalcification and sharp angles in the solid part of the nodule, along with heterogeneous hypoenhancement on contrast-enhanced ultrasound (CEUS), can better predict malignant cystic-solid thyroid nodules. The systematic review and meta-analysis was registered prospectively in the International Prospective Register of Systematic Reviews (No. CRD42024602893).
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