ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2025
NIH Toolbox Cognition Performance in Older Adults with Normal Cognition, Mild Cognitive Impairment, and Mild Dementia of the Alzheimer's Type: Results from the ARMADA Study.
Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Emily H HoDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 625 North Michigan Avenue, Suite 2700, Chicago, IL 60611, USA.ORCID 0000-0002-3522-3779
Tatiana Karpouzian-RogersDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Suite 1100, Chicago, IL 60611, USA.
Ezgi AyturkDepartment of Psychology, Koc University, Rumelifeneri, Sariyer Rumeli, Feneri Yolu, Sariyer, Istanbul 34450, Turkey.
Katy BedjetiDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 625 North Michigan Avenue, Suite 2700, Chicago, IL 60611, USA.
Sandra WeintraubMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, 300 East Superior, 8-715, Chicago, IL 60611, USA.ORCID 0000-0003-2605-5205
Richard GershonDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 625 North Michigan Avenue, Suite 2700, Chicago, IL 60611, USA.
Funding
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9M
Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3M
ARMADA: Advancing Reliable Measurement in Alzheimer's Disease and cognitive Aging - Tech CoreU2CAG057441 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GERSHON, RICHARD, WEINTRAUB, SANDRA · 2017 to 2019
$10.8M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Advancing Reliable Measurement in Alzheimer's Disease and Cognitive AgingColumbia University: Washington Heights-Inwood Columbia Aging ProjectEmory University: Goizueta Alzheimer's Disease Research Center at Emory UniversityMassachusetts ADRC; National Center for Biotechnology Information- Harvard Aging Brain Study P01AG036694Massachusetts General Hospital: Massachusetts Alzheimer's Disease Research Center, National Institute on Aging P30AG062421Mayo Clinic FloridaMichigan Alzheimer's Disease Research Center National Institute on Aging AG054484National Center for Advancing Translational Sciences, National Institutes of Health UL1TR001873National Institute on Aging Cognitive SuperAging studies R01AG045571National Institute on Aging Cognitive SuperAging studies R01AG067781National Institute on Aging Cognitive SuperAging studies R56AG045571National Institute on Aging, Northwestern University AG057441NIA NIH HHS 1P30AG066511NIA NIH HHS AG016574NIA NIH HHS AG058724NIA NIH HHS P30AG062429NIA NIH HHS P30 AG072977NIA NIH HHS PO1AG07232NIA NIH HHS R01AG037212NIA NIH HHS RF1AG054023NIA NIH HHS U2C AG057441NIH HHS AG047866Oregon Health & Science University: Layton Aging and Alzheimer's Disease Center, National Institute on Aging AG066518Treating Mild Cognitive Impairment with High Definition Transcranial Direct Current StimulationUniversity of California, San Diego: UCSD Alzheimer's Disease Research CenterUniversity of Michigan: National Institute on Aging AG053760University of Pittsburgh: Alzheimer's Disease Research Center, National Institute on Aging AG005133University of Pittsburgh Imaging Pathophysiology in Aging and NeurodegenerationUniversity of Pittsburgh National Institute on Aging AG025204University of Wisconsin: Wisconsin Alzheimer's Disease Research Center, National Institute on Aging AG033514University of Wisconsin: Wisconsin Alzheimer's Disease Research Center, National Institute on Aging AG062715Young-Old National Institute on Aging AG052446
6 · The paper itself
Abstract
objectiveEfficient and early detection of cognitive impairment may be facilitated using the NIH Toolbox (NIHTB), a computerized suite of assessments measuring multiple aspects of neurological functioning.
methodsThe Advancing Reliable Measurement in Alzheimer's Disease and cognitive Aging study validated the NIHTB across a geographically diverse cognitive aging sample. Participants aged >64 with normal cognition (NC), mild cognitive impairment (MCI), and dementia of the Alzheimer type (DAT) across nine research sites completed the NIHTB. One-way ANOVAs captured differences in performance on the Cognition Battery and effect sizes were calculated.
resultsGroups differed substantially across all cognition measures, with large differences in Total and Fluid Cognition, after demographic adjustment. The largest differentiators were in fluid measures, particularly for working and episodic memory.
conclusionsNIHTB-CB differentiates NC, MCI, and DAT groups. Future studies will examine longitudinal differences and performance in enriched samples (African American participants, Spanish NIHTB, 85+ years old).
Indexed as
Alzheimer DiseaseCognitionCognitive DysfunctionNeuropsychological TestsAgedAged, 80 and overFemaleHumansMaleMiddle AgedNational Institutes of Health (U.S.)United StatesAgingAlzheimer’s diseaseCognitionDementiaMild cognitive impairmentNIH Toolbox
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
NIH Toolbox Cognition Performance in Older Adults with Normal Cognition, Mild Cognitive Impairment, and Mild Dementia of the Alzheimer's Type: Results from the ARMADA Study. · full record | OpenQuestion