Evidence map›Paper›PMID 40364160›Full record

ArticleJournal of clinical medicine2025

EGFR-Mutant Urothelial Carcinoma Harboring an Ala750_Ile759delinsGlyGly Alteration with a Primary Resistance to Polychemotherapy and a Sensitivity to Osimertinib: A Literature Review on EGFR Alterations and Response to EGFR Tyrosine Kinase Inhibitors in Cancers.

Jean-Baptiste Barbe-Richaud, Antonin Fattori, Véronique Lindner, Caroline Schuster, Gabriel Malouf, Erwan Pencreach, Laura Somme

Abstract readCase Reports
In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jean-Baptiste Barbe-RichaudOncology Department, Institut de Cancérologie Strasbourg Europe, 17 Rue Albert Calmette, 67200 Strasbourg, France.
Antonin FattoriPathological Department, Hôpital de Hautepierre, 1 Avenue Molière, 67200 Strasbourg, France.ORCID 0000-0002-0249-4935
Véronique LindnerPathological Department, Hôpital de Hautepierre, 1 Avenue Molière, 67200 Strasbourg, France.ORCID 0000-0001-5140-5321
Caroline SchusterOncology Department, Institut de Cancérologie Strasbourg Europe, 17 Rue Albert Calmette, 67200 Strasbourg, France.
Gabriel MaloufOncology Department, Institut de Cancérologie Strasbourg Europe, 17 Rue Albert Calmette, 67200 Strasbourg, France.
Erwan PencreachMolecular Departement, Hôpital de Hautepierre, 1 Avenue Molière, 67200 Strasbourg, France.
Laura SommeOncology Department, Institut de Cancérologie Strasbourg Europe, 17 Rue Albert Calmette, 67200 Strasbourg, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urothelial carcinoma is three to four times more common in men than in women, with a 73-year old mean age at diagnosis which is older than the average age at diagnosis of all cancers. Urothelial carcinoma is rare in people under 40 years of age. Smoking, exposure to industrial chemicals, and family history influence the development of bladder cancer, but age remains one of the most important risk factors. It is well established that women are more likely to be diagnosed with an advanced disease, impacting the prognosis and a higher stage-for-stage mortality compared to men. A gender difference is also observed when considering molecular features; for example, there a higher male/female ratio in

Indexed as

deletion exon 19EGFRosimertinibkey pointsuncommon mutationurothelial carcinoma

Identifiers

PMID40364160
PMCPMC12072851

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.