Evidence map›Paper›PMID 40363876›Full record

ArticleMolecules (Basel, Switzerland)2025

Rationally Designed Pentapeptide Analogs of Aβ19-23 Fragment as Potent Inhibitors of Aβ42 Aggregation.

Sachin B Baravkar, Yan Lu, Qi Zhao, Hongying Peng, Weilie Zhou, Song Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sachin B BaravkarNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health, New Orleans, LA 70112, USA.
Yan LuNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health, New Orleans, LA 70112, USA.
Qi ZhaoNMR Laboratory, Department of Chemistry, Tulane University, New Orleans, LA 70115, USA.ORCID 0009-0006-9494-1398
Hongying PengDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45221, USA.
Weilie ZhouDepartment of Physics & Adavanced Materials Research Institute (AMRI), University of New Orleans, New Orleans, LA 70148, USA.
Song HongNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health, New Orleans, LA 70112, USA.

Funding

A Novel Resolution Strategy on Chronic Inflammation and Impaired Healing of Wounds in AgingR21AG066119 · NIA · LSU HEALTH SCIENCES CENTER · PI HONG, SONG · 2020 to 2021
$805k
SPM BIODEGRADATION: A NOVEL MECHANISM FOR IMPAIRED HEALING OF CHRONIC WOUNDS IN AGINGR21AG060430 · NIA · LSU HEALTH SCIENCES CENTER · PI HONG, SONG · 2018 to 2019
$771k
Explore the Comparative Biology on Effects of Skin Ulceration on AD-Pathological NeurodegenerationR21AG068756 · NIA · LSU HEALTH SCIENCES CENTER · PI HONG, SONG · 2020 to 2022
$422k
NIA NIH HHS R21 AG060430NIA NIH HHS R21 AG066119NIA NIH HHS R21 AG068756NIH HHS R21AG060430, R21AG066119, R21AG068756 and R01GM136874
6 · The paper itself

Abstract

Amyloid beta (Aβ42 and Aβ40) aggregation, along with neurofibrillary tangles, is one of the major neurotoxic events responsible for the onset of Alzheimer's disease. Many potent peptide-based inhibitors mainly focusing on central hydrophobic core Aβ16-20 (KLVFF) have been reported in recent years. Herein, we report pentapeptides

Indexed as

Amyloid beta-PeptidesOligopeptidesPeptide FragmentsProtein AggregatesCircular DichroismDrug DesignHumansAmyloid beta-Peptidesamyloid beta-protein (1-42)OligopeptidesPeptide FragmentsProtein AggregatesAlzheimer’s diseaseamyloid beta aggregation inhibitorcircular dichroismHSQC NMRpentapeptidesthioflavin T fluorescence assaytransmission electron microscopy TEM

Identifiers

PMID40363876
PMCPMC12073614

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.