Evidence map›Paper›PMID 40363807›Full record

ArticleMolecules (Basel, Switzerland)2025

A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network.

Lidia Boghean, Sarbjit Singh, Kiran K Mangalaparthi, Smitha Kizhake, Lelisse Umeta, Donn Wishka, Paul Grothaus, Akhilesh Pandey, Amarnath Natarajan

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lidia BogheanEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-3830-3560
Sarbjit SinghEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-5719-967X
Kiran K MangalaparthiDepartment of Laboratory Medicine and Pathology, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-5791-727X
Smitha KizhakeEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Lelisse UmetaEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Donn WishkaDrug Synthesis and Chemistry Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Paul GrothausDrug Synthesis and Chemistry Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-9943-6127
Amarnath NatarajanEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-5067-0203

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
CHEMICAL CARCINOGENESIS &CANCER BIOLOGYT32CA009476 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Jennifer D. Black · 1988 to 2026
$6.2M
Development of Quinoxaline Based IKKbeta Inhibitors for Kras Driven CancersR01CA197999 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Amarnath (Amar) Natarajan · 2016 to 2026
$3.3M
NCI NIH HHS P30 CA015083NCI NIH HHS T32 CA009476NIH HHS R01 CA197999
6 · The paper itself

Abstract

The quinoxaline core is found in several biologically active compounds, with Erdafitinib being the first FDA-approved quinoxaline derivative that targets a kinase and exhibits anti-cancer properties. We previously reported a quinoxaline analog (

Indexed as

Nuclear ProteinsProtein Kinase InhibitorsAnimalsHumansNucleophosminProteomicsQuinoxalinesNPM1 protein, humanNuclear ProteinsNucleophosminProtein Kinase InhibitorsQuinoxalinesMAP3K1 inhibitorNPM1phosphoproteomicsquinoxaline

Identifiers

PMID40363807
PMCPMC12073402

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.