ArticleMolecules (Basel, Switzerland)2025
Drug Repurposing to Inhibit Oncostatin M in Crohn's Disease.
Faranak Bahramimehr, Axel Guthart, Stefanie Kurz, Yuanping Hai, Mona Dawood, Rümeysa Yücer, Nasim Shahhamzehei, Ralf Weiskirchen, Wilfried Roth, Wolfgang Stremmel and 2 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Faranak BahramimehrDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.ORCID 0009-0008-1845-586X Axel GuthartDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Stefanie KurzDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Yuanping HaiDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.ORCID 0000-0003-1709-6996 Mona DawoodDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Rümeysa YücerDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.ORCID 0000-0002-9678-3323 Nasim ShahhamzeheiDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.ORCID 0000-0001-9454-3599 Ralf WeiskirchenInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, 52074 Aachen, Germany.ORCID 0000-0003-3888-0931 Wilfried RothInstitute of Pathology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Gerhard BringmannInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID 0000-0002-3583-5935 Thomas EfferthDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.ORCID 0000-0002-2637-1681 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Crohn's disease is an inflammatory bowel disease (IBD) that currently lacks satisfactory treatment options. Therefore, new targets for new drugs are urgently needed to combat this disease. In the present study, we investigated the transcriptomics-based mRNA expression of intestinal biopsies from patients with Crohn's disease. We compared the mRNA expression profiles of the ileum and colon of patients with those of healthy individuals. A total of 72 genes in the ileum and 33 genes in the colon were differentially regulated. Among these, six genes were overexpressed in both tissues, including
Indexed as
Crohn DiseaseDrug RepositioningIntestinesOncostatin MAnimalsBiopsyDrug Evaluation, PreclinicalGene Expression ProfilingGene Expression RegulationHumansMice, KnockoutRNA, MessengerOncostatin MRNA, Messengerchronic inflammationinflammatory bowel diseasemicroscale thermophoresismolecular dockingtranscriptomicsvirtual drug screening
Identifiers
PMID40363705
PMCPMC12073679
What OpenQuestion holds
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LicenceCC BY
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