ArticleMaterials (Basel, Switzerland)2025
Iron Oxide Magnetic Nanoparticles Synthesized by Laser Target Evaporation Method for the Needs of Cancer Immunotherapy.
Article in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Administration of monocyte-derived dendritic cells (moDCs) sensitized by cancer-associated antigens to the patient is applied to boost the T-cell mediated anti-tumor immune response. Loading moDCs with magnetic nanoparticles (MNPs) and controlling their migration to lymph nodes by an external magnetic field is a way to improve the effectiveness of immunotherapy. In this study, spherical MNPs of maghemite iron oxide with a diameter of about 14 nm were synthesized by laser target evaporation method (LTE) and examined in the context of their prospective use for the needs of moDCs immunotherapy. Characterization of the physicochemical properties of MNPs and their stabilization in physiological media, as well as the magnetic properties of MNPs in the suspensions were considered in detail. The cytotoxic effect of MNPs in growth medium on the human moDCs and MNPs uptake by the cells were also estimated. We show that up-taken MNPs and MNPs in growth medium demonstrated cytotoxic effect only at high concentrations. At the same time, at low concentrations MNPs up-taken by moDCs increased their viability causing the stimulation effect. The evaluation of the quantity of MNPs, up-taken by cells, is possible by magnetometry even for the smallest γ-Fe
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.