Evidence map›Paper›PMID 40363594›Full record

ArticleMaterials (Basel, Switzerland)2025

Synthesis and Osteoinductive Properties of Nanosized Lithium-Modified Calcium-Organic Frameworks.

Daniel Vargas, Daniel Peña, Emma Whitehead, Warren L Grayson, Benjamin P Le Monnier, Michael Tsapatsis, Patricio Romero-Hasler, Rocío Orellana, Miguel Neira, Cristian Covarrubias

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel VargasLaboratory of Nanobiomaterials, Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago 8320000, Chile.
Daniel PeñaLaboratory of Nanobiomaterials, Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago 8320000, Chile.ORCID 0009-0004-4359-2728
Emma WhiteheadDepartment of Biomedical Engineering, School of Medicine, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21201, USA.ORCID 0000-0003-3960-5640
Warren L GraysonDepartment of Biomedical Engineering, School of Medicine, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21201, USA.
Benjamin P Le MonnierDepartment of Chemical and Biomolecular Engineering, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21201, USA.
Michael TsapatsisDepartment of Chemical and Biomolecular Engineering, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21201, USA.
Patricio Romero-HaslerDepartment of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8320000, Chile.ORCID 0000-0002-9211-2514
Rocío OrellanaLaboratory of Nanobiomaterials, Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago 8320000, Chile.
Miguel NeiraLaboratory of Nanobiomaterials, Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago 8320000, Chile.
Cristian CovarrubiasLaboratory of Nanobiomaterials, Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago 8320000, Chile.

Funding

Ministry of Science, Technology, Knowledge and Innovation FONDECYT 1211314
6 · The paper itself

Abstract

The development of biomaterials that enhance bone healing and integrate with native bone tissue has gained significant interest. Metal-organic frameworks (MOFs) have emerged as promising candidates due to their unique surface properties and biocompatibility. While various bioactive element-incorporated MOFs have been studied, the osteogenic potential of lithium (Li)-modified MOFs remains largely unexplored. This study presents the synthesis and characterization of a nanosized calcium-based MOF incorporating Li⁺ ions to enhance osteoinductive properties. The MOFs were evaluated in vitro for apatite mineralization, degradation, ion release, protein adsorption, cell adhesion, viability, and osteogenic differentiation using pre-osteoblast cells. The synthesized MOFs promoted apatite formation under simulated physiological conditions, facilitated by their surface nucleation properties, controlled degradation, and sustained Li

Indexed as

bone regenerationcalciumlithiummetal-organic frameworks (MOFs)osteoinductive nanoparticles

Identifiers

PMID40363594
PMCPMC12072901

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.