Evidence map›Paper›PMID 40363455›Full record

ArticleMaterials (Basel, Switzerland)2025

A Novel Pre-Customized Saddle-Shape Soft Tissue Substitute for Volume Augmentation: An Ex Vivo Study in Pig Mandibles.

Malin Strasding, Irena Sailer, Elizabeth Merino-Higuera, Cristina Zarauz, Joao Pitta, Andrei Latyshev, Udo Wittmann, Dobrila Nesic

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Malin StrasdingDivision of Fixed Prosthodontics and Biomaterials, University Clinic of Dental Medicine, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland.ORCID 0000-0003-1679-6202
Irena SailerDivision of Fixed Prosthodontics and Biomaterials, University Clinic of Dental Medicine, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland.ORCID 0000-0002-4537-7624
Elizabeth Merino-HigueraDivision of Fixed Prosthodontics and Biomaterials, University Clinic of Dental Medicine, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland.ORCID 0000-0001-5118-3212
Cristina ZarauzDivision of Fixed Prosthodontics and Biomaterials, University Clinic of Dental Medicine, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland.
Joao PittaDivision of Fixed Prosthodontics and Biomaterials, University Clinic of Dental Medicine, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland.ORCID 0000-0002-2334-4688
Andrei LatyshevDivision of Fixed Prosthodontics and Biomaterials, University Clinic of Dental Medicine, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland.
Udo WittmannConsult AG Statistical Services, Thurgauerstrasse 36, CH-8050 Zurich, Switzerland.
Dobrila NesicDivision of Fixed Prosthodontics and Biomaterials, University Clinic of Dental Medicine, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland.ORCID 0000-0003-1609-9255

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTooth loss results in hard- and soft-tissue volume loss over time. We compared the handling of three different soft tissue substitutes (STS) to the subepithelial connective tissue graft (SCTG) for soft tissue volume augmentation in a pig ex vivo model.

methodsFive dentists simultaneously shaped, placed and sutured randomized four graft types in single-tooth soft tissue defects created in pig mandibles. The STS, produced from slightly crosslinked collagen fibres (VCMX), were either 3 mm or 6 mm thick blocks or a newly developed pre-customized saddle-shape. Each graft type was handled 20 times. The time required for shaping, placement, and suturing was recorded. Dentists reported outcomes on the grafts' handling were evaluated with a visual-analogue-scale (VAS). Statistical analysis included calculating means and medians and testing significance.

resultsThe mean time of 0.72 min for shaping the pre-customized saddle-shape STS was significantly lower than 1.31 min for SCTG, 1.73 min for 3 mm STS and 2.17 min for 6 mm STS. Placement/suturing time was similar for all grafts. The dentists mainly preferred the saddle-shape STS and the SCTG.

conclusionsThe saddle-shape STS required less time for graft-shaping and, therefore, reduced the overall treatment time, suggesting a more efficient and less invasive workflow for soft tissue augmentation.

Indexed as

customized graftFibro-Gidepersonalized dental medicinesoft tissue substitutessoft tissue volume augmentationsubepithelial connective tissue graft

Identifiers

PMID40363455
PMCPMC12072894

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.