Evidence map›Paper›PMID 40362983›Full record

ArticlePolymers2025

Ammonium-Containing Methacrylic Polymer Brushes with Adjustable Hydrophilicity: Synthesis and Properties in Aqueous Solutions.

Denis Kamorin, Alexander Simagin, Oleg Kazantsev, Maria Savinova, Maria Simonova, Denis Sadkov, Ildar Arifullin, Yaroslav Dolinov

Abstract read
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In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Denis KamorinResearch Laboratory "New Polymeric Materials", Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin Street, 603950 Nizhny Novgorod, Russia.ORCID 0000-0002-8712-5062
Alexander SimaginResearch Laboratory "New Polymeric Materials", Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin Street, 603950 Nizhny Novgorod, Russia.ORCID 0000-0002-6985-2098
Oleg KazantsevResearch Laboratory "New Polymeric Materials", Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin Street, 603950 Nizhny Novgorod, Russia.
Maria SavinovaResearch Laboratory "New Polymeric Materials", Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin Street, 603950 Nizhny Novgorod, Russia.
Maria SimonovaLaboratory of Biomimetic Polymer Materials, Branch of Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute»-Institute of Macromolecular Compounds, Bolshoy Prospekt 31, 199004 Saint Petersburg, Russia.
Denis SadkovLaboratory of Biomimetic Polymer Materials, Branch of Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute»-Institute of Macromolecular Compounds, Bolshoy Prospekt 31, 199004 Saint Petersburg, Russia.
Ildar ArifullinResearch Laboratory "New Polymeric Materials", Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin Street, 603950 Nizhny Novgorod, Russia.
Yaroslav DolinovResearch Laboratory "New Polymeric Materials", Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin Street, 603950 Nizhny Novgorod, Russia.

Funding

Russian Science Foundation 22-73-10220
6 · The paper itself

Abstract

Reversible addition-fragmentation chain-transfer (RAFT) polymerization was used to synthesize novel thermoresponsive cationic molecular brushes with high yields-namely of copolymers of methoxyoligo(ethylene glycol) methacrylate, alkoxyoligo(ethylene glycol) methacrylate, and N-methacryloylaminopropyl-N,N-dimethyl-N-propylammonium bromide. Controlled polymerization yielded polymers with a molecular weight dispersity of ≤1.3 and conversions exceeding 80%. The influence of the cationic molecular brushes' composition on their solubility in water and organic solvents, interfacial tension at the water-oil interface, and aggregation behavior in aqueous solutions was investigated. For the first time, we report the design of thermoresponsive cationic molecular brushes combining an antibacterial potential and tunable hydrophilic-hydrophobic properties, enabling highly precise control over their LCST behavior (17-68 °C) through composition tuning. The solubilization capacity of the hydrophobic compounds of brush micelles in water increased with the hydrophobic comonomer content. These polymers exhibited interfacial activity, significantly reducing the water-oil interfacial tension, with critical micelle concentrations (CMCs) of 3-10 mg/L. It was shown that the amphiphilic properties of the copolymers in aqueous solutions can be easily tuned in a desired direction by varying the content of the comonomer units. The obtained data indicate the potential of the polymers as micellar nanocarriers for controlled drug delivery.

Indexed as

amphiphilic polymersdialkylaminoalkyl methacrylamidemicellesoligo(ethylene glycol) methacrylateRAFT polymerizationthermoresponsive polymers

Identifiers

PMID40362983
PMCPMC12073613

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