ArticlePolymers2025
Nano-Hydroxyapatite/Poly(methyl methacrylate) Composite Bone Scaffold: Surfactant Surface Effects.
Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nanohydroxyapatite and its composite scaffold for bone tissue engineering application: a systematic review.Journal of materials science. Materials in medicine · 2025Pooled it
- MAPLE Deposition of Resorbable Calcium Phosphates on Electrospun Nylon Nanofibres for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Article
- Effect of Phosphate Phase Incorporation on 3D-Printed Hydrogel Scaffolds: Towards Customizable Bone Graft Materials.Gels (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, poly(methyl methacrylate) (PMMA) nanofiber scaffolds reinforced with synthesized nano-hydroxyapatite (n-HA) were fabricated through electrospinning to enhance their potential for applications in bone tissue engineering. Sodium tripolyphosphate (STTP) was utilized as a surfactant to achieve a uniform distribution of particles and improve the structural integrity of the scaffolds. PMMA solutions were prepared at concentrations of the addition of STTP effectively stabilized n-HA dispersion, leading to enhanced fiber morphology, as confirmed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM). The PMMA_10_HA_S nanofibers demonstrated a homogeneous fiber distribution with an average diameter of 345.40 ± 53.55 nm and a calcium content of 7.1%. Mechanical testing revealed that adding STTP enhanced the mechanical properties, with the n-HA-reinforced 10 wt.% PMMA nanofibers achieving a maximum tensile stress of 4.16 ± 2.13 MPa and an elongation of 7.1 ± 1.95%. Furthermore, cell cytotoxicity assays of different concentrations (25, 50, 75, and 100 mg/mL) using L929 fibroblast cells demonstrated no cytotoxic effect of PMMA_10_HA_S nanofibers. These findings, reinforced by STTP and n-HA, highlight the potential of PMMA_10_HA_S nanofiber scaffolds as promising candidates for bone tissue applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.