Evidence map›Paper›PMID 40362905›Full record

ArticleNutrients2025

Anti-Hyperuricemic and Nephroprotective Effects of Hydrolysate Derived from Silkworm Pupae (

Yuting Fan, Zhencong Yang, Xiao Lin, Zhoujin Xu, Lixia Mu, Qingrong Li, Xuli Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuting FanSchool of Public Health, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Zhencong YangSchool of Public Health, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Xiao LinSchool of Public Health, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Zhoujin XuSchool of Public Health, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Lixia MuSericulture and Agro-Processing Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
Qingrong LiSericulture and Agro-Processing Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
Xuli WuSchool of Public Health, Health Science Center, Shenzhen University, Shenzhen 518060, China.

Funding

Key Project of Department of Education of Guangdong Province 2024ZDZX2020National Natural Science Foundation of China 32172311National Natural Science Foundation of China 32472448Shenzhen Science and Technology Program JCYJ20220531102205012
6 · The paper itself

Abstract

backgroundHyperuricemia is a prevalent metabolic disorder characterized by elevated serum uric acid (UA) levels.

methodsIn this study, hydrolysate (SPP) derived from silkworm pupae protein was isolated and identified, demonstrating anti-hyperuricemic activity. The research aimed to investigate its anti-hyperuricemic and nephroprotective effects, along with potential mechanisms, through in vitro assays and in vivo experiments using potassium oxonate/hypoxanthine-induced hyperuricemic mice.

resultsThe SPP exhibited significant xanthine oxidase (XOD) inhibitory activity, with an IC

conclusionsThese findings suggest that SPP possesses a notable urate-lowering efficacy and renal protective properties, highlighting its potential as a therapeutic agent for the management and prevention of hyperuricemia (HUA).

Indexed as

BombyxHyperuricemiaProtein HydrolysatesAnimalsATP Binding Cassette Transporter, Subfamily G, Member 2Blood Urea NitrogenCreatinineCytokinesDisease Models, AnimalKidneyMaleMiceOrganic Anion Transport Protein 1Oxonic AcidUric AcidXanthine OxidaseATP Binding Cassette Transporter, Subfamily G, Member 2CreatinineCytokinesOrganic Anion Transport Protein 1Oxonic Acidpotassium oxonateProtein HydrolysatesUric AcidXanthine Oxidaseanti-hyperuricemicanti-inflammatorypeptidessilkworm pupaexanthine oxidase

Identifiers

PMID40362905
PMCPMC12073332

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.