Evidence map›Paper›PMID 40362863›Full record

ReviewNutrients2025

Nutraceuticals for Gut-Brain Axis Health: A Novel Approach to Combat Malnutrition and Future Personalised Nutraceutical Interventions.

Litai Liu, Wen Qi, Na Zhang, Jinhao Zhang, Shen Liu, Huan Wang, Lianzhou Jiang, Ying Sun

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Litai LiuTourism & Cuisine College, Harbin University of Commerce, Harbin 150028, China.ORCID 0009-0006-0770-319X
Wen QiTourism & Cuisine College, Harbin University of Commerce, Harbin 150028, China.ORCID 0009-0000-8507-9050
Na ZhangTourism & Cuisine College, Harbin University of Commerce, Harbin 150028, China.ORCID 0000-0002-5706-641X
Jinhao ZhangCollege of Food Science, Northeast Agricultural University, Harbin 150030, China.
Shen LiuTourism & Cuisine College, Harbin University of Commerce, Harbin 150028, China.
Huan WangCollege of Food Science, Northeast Agricultural University, Harbin 150030, China.
Lianzhou JiangCollege of Food Science, Northeast Agricultural University, Harbin 150030, China.
Ying SunTourism & Cuisine College, Harbin University of Commerce, Harbin 150028, China.

Funding

National Natural Science Foundation of China 32372386Natural Science Foundation of Heilongjiang Province LH 2022C048
6 · The paper itself

Abstract

The gut-brain axis (GBA) is a bidirectional communication network between the gastrointestinal tract and the brain, modulated by gut microbiota and related biomarkers. Malnutrition disrupts GBA homeostasis, exacerbating GBA dysfunction through gut dysbiosis, impaired neuroactive metabolite production, and systemic inflammation. Nutraceuticals, including probiotics, prebiotics, synbiotics, postbiotics, and paraprobiotics, offer a promising approach to improving GBA homeostasis by modulating the gut microbiota composition and related neuroactive metabolites. This review aims to elucidate the interplay between gut microbiota-derived biomarkers and GBA dysfunction in malnutrition and evaluate the potential of nutraceuticals in combating malnutrition. Furthermore, it explores the future of personalised nutraceutical interventions tailored to individual genetic and microbiome profiles, providing a targeted approach to optimise health outcomes. The integration of nutraceuticals into GBA health management could transform malnutrition treatment and improve cognitive and metabolic health.

Indexed as

BrainBrain-Gut AxisDietary SupplementsGastrointestinal MicrobiomeMalnutritionBiomarkersDysbiosisHumansPrebioticsPrecision MedicineProbioticsBiomarkersPrebioticsgut–brain axisgut microbiotamalnutritionnutraceuticalpersonalised nutraceuticals

Identifiers

PMID40362863
PMCPMC12073618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.