Evidence map›Paper›PMID 40362846›Full record

ArticleNutrients2025

Inhibition Mechanism of Mulberry Prenylated Flavonoids Sanggenone D/Kuwanon G Against α-Glucosidase and the Regulation of Glucose via GLUT4 Pathway.

Erwen Wu, Yanqing Zhu, Qingyi Wei, Huijie Lu, Yuxiao Zou, Fan Liu, Qian Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Dual action of herbal compounds inFrontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erwen WuKey Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing; Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China.
Yanqing ZhuKey Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing; Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China.
Qingyi WeiSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Huijie LuInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
Yuxiao ZouKey Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing; Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China.
Fan LiuKey Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing; Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China.ORCID 0000-0001-6474-244X
Qian LiKey Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing; Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China.ORCID 0000-0003-3366-966X

Funding

the Science & Technology Projects of Guangdong Province No.2024A1515011122; No. 2023B0202010004
6 · The paper itself

Abstract

backgroundInhibition of α-glucosidase activity is recognized as an effective strategy for managing type 2 diabetes.

methodsThe inhibitory mechanisms of two kinds of mulberry flavonoids, namely sanggenone D and kuwanon G, on α-glucosidase were investigated and the hypoglycemic pathways were explored in the current study.

resultsThe outcomes indicate that sanggenone D (IC

conclusionsThe results provided useful reference for the application of sanggenone D and kuwanon G in hypoglycemic functional components.

Indexed as

alpha-GlucosidasesFlavonoidsGlucoseGlucose Transporter Type 4Glycoside Hydrolase InhibitorsMorusAnimalsHumansHypoglycemic AgentsMolecular Docking SimulationPlant Extractsalpha-GlucosidasesFlavonoidsGlucoseGlucose Transporter Type 4Glycoside Hydrolase InhibitorsHypoglycemic AgentsPlant Extractsinhibition mechanismsmolecular dockingstructure–activity relationshipWestern blottingα-glucosidase

Identifiers

PMID40362846
PMCPMC12073159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.