Evidence map›Paper›PMID 40362825›Full record

ReviewNutrients2025

Research Progress of Oral Immune Tolerance Mechanism Induced by Whey Protein.

Mao Lin, Qianqian Zhang, Yanjun Cong

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mao LinCollege of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Qianqian ZhangCollege of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Yanjun CongCollege of Food and Health, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0003-1473-2440

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cow milk allergy (CMA) is prevalently observed among infants and young children, exerting adverse effects on their growth and quality of life. Oral immune tolerance (OIT) is a more effective method for the prevention and treatment of CMA. The site of OIT is mainly in the gastrointestinal tract, so this article reviews the composition and structural characteristics of intestinal immune system, the molecular mechanisms of immune tolerance by regulatory T cells (Treg), dendritic cells, and gut microbiota. In addition, this paper summarizes the research progress of T cell epitope peptides of β-lactoglobulin and α-lactalbumin in whey protein hydrolysates. The mechanism of OIT induced by whey protein hydrolysate or whey protein combined with other anti-allergic components (phenolic compounds, probiotics, etc.) is overviewed to provide new ideas for the development of hypoallergenic infant formula.

Indexed as

Immune ToleranceMilk HypersensitivityWhey ProteinsAnimalsDendritic CellsEpitopes, T-LymphocyteGastrointestinal MicrobiomeHumansInfantInfant FormulaLactalbuminLactoglobulinsProtein HydrolysatesT-Lymphocytes, RegulatoryEpitopes, T-LymphocyteLactalbuminLactoglobulinsProtein HydrolysatesWhey Proteinscow milk allergyhydrolyzed whey proteinhypoallergenicityoral immune tolerance mechanism

Identifiers

PMID40362825
PMCPMC12073718

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.