Evidence map›Paper›PMID 40362654›Full record

ArticleInternational journal of molecular sciences2025

Topological Distribution of the Sex Hormone Receptor Expressions Highlights the Importance of Stromal ERα and Epithelial PR in Malignant Transformation of the Uterine Cervix.

Mun-Kun Hong, Jen-Hung Wang, Ming-Hsun Li, Cheng-Chuan Su, Chiu-Hsuan Cheng, Tang-Yuan Chu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mun-Kun HongDepartment of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Hualien 97004, Taiwan.
Jen-Hung WangDepartment of Medical Research, Hualien Tzu Chi Hospital, Hualien 97004, Taiwan.
Ming-Hsun LiDepartment of Pathology, Hualien Tzu Chi Hospital, Hualien 97004, Taiwan.
Cheng-Chuan SuSchool of Medicine, Tzu Chi University, Hualien 97004, Taiwan.ORCID 0000-0002-9846-1571
Chiu-Hsuan ChengDepartment of Pathology, Hualien Tzu Chi Hospital, Hualien 97004, Taiwan.ORCID 0000-0002-9996-0428
Tang-Yuan ChuDepartment of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Hualien 97004, Taiwan.

Funding

Hualien Tzu Chi Hospital, Hualien, Taiwan, R.O.C TCRD105-25Ministry of Science and Technology, Taiwan, R.O.C. MOST 105-2314-B-303-005
6 · The paper itself

Abstract

To investigate the changes of ERα and PRs in the epithelium and stroma of normal and neoplastic uterine cervix. Two pathologists independently scored the expression levels of ERα, PR(A+B), and PRB in the stroma and epithelium of normal, cervical intraepithelial neoplasia grade 2 and 3 (CIN2/3), carcinoma in situ (CIS), and invasive cervical carcinoma (ICC) specimens. Sex hormone receptors were abundantly expressed in the stroma compared to the epithelium or carcinoma of the cervix. Stromal ERα was progressively upregulated during cervical carcinogenesis, with an immunoreactive score (IRS) of 1.3 ± 1.5, 2.1 ± 1.9, and 3.6 ± 3.3 in the CIN2/3, CIS, and ICC groups, respectively (

Indexed as

Cell Transformation, NeoplasticCervix UteriEstrogen Receptor alphaReceptors, ProgesteroneUterine Cervical NeoplasmsAdultEpithelial CellsFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedStromal CellsUterine Cervical DysplasiaESR1 protein, humanEstrogen Receptor alphaReceptors, Progesteronecervical cancermalignant transformationmetastasisprogesterone receptor Bstroma

Identifiers

PMID40362654
PMCPMC12073007

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.