Evidence map›Paper›PMID 40362644›Full record

ArticleInternational journal of molecular sciences2025

MicroRNA Is Downregulated in Invasive Non-Functioning Pituitary Adenomas.

Aleksandra Derwich-Rudowicz, Aleksandra Żbikowska, Marek Ruchała, Mirosław Andrusiewicz, Jakub Moskal, Nadia Sawicka-Gutaj

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aleksandra Derwich-RudowiczDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland.ORCID 0000-0003-0413-2679
Aleksandra ŻbikowskaDepartment of Cell Biology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznań, Poland.ORCID 0000-0002-6891-8569
Marek RuchałaDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland.ORCID 0000-0002-6296-7220
Mirosław AndrusiewiczDepartment of Cell Biology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznań, Poland.ORCID 0000-0002-8781-3447
Jakub MoskalDepartment of Neurosurgery, Poznan University of Medical Science, Przybyszewskiego 49, 60-355 Poznań, Poland.
Nadia Sawicka-GutajDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland.ORCID 0000-0003-1510-4702

Funding

Poznan University of Medical Sciences 45092/DGB/2024, 147/2024/MGB
6 · The paper itself

Abstract

The study aimed to analyze hsa-miR-16-5p, hsa-miR-143-3p, hsa-miR-423-5p, hsa-miR-137-3p, hsa-miR-489-5p, hsa-miR-520-3p, hsa-miR-486-5p, and hsa-miR-200a-3p expression in the serum of patients with invasive non-functioning pituitary adenomas (NFPAs) and prolactinomas, as candidates for non-invasive biomarkers. The study included 62 patients with NFPAs and 18 with macroprolactinoma who qualified for transsphenoidal surgical resection. MicroRNAs were isolated from serum samples. The expression levels of hsa-miR-16-5p, hsa-miR-143-3p, hsa-miR-423-5p, hsa-miR-137-3p, hsa-miR-489-5p, hsa-miR-520-3p, hsa-miR-486-5p, and hsa-miR-200a-3p were determined using TaqMan MicroRNA assays. The statistical analyses were performed with MedCalc. The total concentration of microRNA was significantly lower in NFPAs than in the CG (

Indexed as

AdenomaDown-RegulationGene Expression Regulation, NeoplasticMicroRNAsPituitary NeoplasmsProlactinomaAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedNeoplasm InvasivenessROC CurveBiomarkers, TumorMicroRNAsinvasive pituitary adenomamiRNApituitary tumorprolactinoma

Identifiers

PMID40362644
PMCPMC12072200

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.