Evidence map›Paper›PMID 40362618›Full record

ReviewInternational journal of molecular sciences2025

Body Fluid-Derived Stem Cells: Powering Innovative, Less-Invasive Cell Therapies.

Adam David Goff, Xinyue Zhang, Biju Thomas, Sally Shin Yee Ong, Anthony Atala, Yuanyuan Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adam David GoffWake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC 27101, USA.
Xinyue ZhangWake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC 27101, USA.
Biju ThomasKeck School of Medicine of USC, University of Southern California, Los Angeles, CA 90033, USA.
Sally Shin Yee OngDepartment of Ophthalmology, School of Medicine, Wake Forest University, Winston-Salem, NC 27101, USA.ORCID 0000-0003-3599-9021
Anthony AtalaWake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC 27101, USA.ORCID 0000-0001-8186-2160
Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC 27101, USA.ORCID 0000-0002-5708-9718

Funding

National Institute of Allergy and Infectious Diseases, National Institutes of Health Contract No. Funding Sources NEI, R21 EY0358332024; HIAID, R21 AI152832, R03 AI165170; HHSN272201400006I; NIDDK, R21DK071791; R56DK100669 (PI: Yuanyuan Zhang).
6 · The paper itself

Abstract

Stem cell therapy offers significant promise for tissue regeneration and repair. Traditionally, bone marrow- and adipose-derived stem cells have served as primary sources, but their clinical use is limited by invasiveness and low cell yield. This review focuses on body fluid-derived stem cells as an emerging, non-invasive, and readily accessible alternative. We examine stem cells isolated from amniotic fluid, peripheral blood, cord blood, menstrual fluid, urine, synovial fluid, breast milk, and cerebrospinal fluid, highlighting their unique biological properties and therapeutic potential. By comparing their characteristics and barriers to clinical translation, we propose body fluid-derived stem cells as a promising source for regenerative applications, with continued research needed to fully achieve their clinical utility.

Indexed as

Body FluidsCell- and Tissue-Based TherapyStem CellsStem Cell TransplantationAnimalsHumansbody fluid-derived stem cellspersonalized medicineregenerationstem cell therapy

Identifiers

PMID40362618
PMCPMC12072510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.