ArticleInternational journal of molecular sciences2025
Non-Oxidised Parathyroid Hormone and a Panel of Markers of Calcium-Phosphate Metabolism for Analysis of Secondary Hyperparathyroidism in Selected Patient Groups-A Quality Assurance Project.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Intact parathyroid hormone (PTHi) plays a central role in the regulation of mineral and bone metabolism. Due to post-translational modifications of the hormone, the interpretation of elevated PTHi values is challenging and may benefit from an expanded analytical panel. Within this project, additional parameters of calcium-phosphate metabolism, such as non-oxidised parathyroid hormone (noxPTH), calcidiol, vitamin D binding protein (VDBP), and fibroblast growth factor 23 (FGF23) were evaluated in a control population of 177 individuals as well as 182 patients with renal, gastroenterological, and liver diseases. While PTHi and noxPTH levels were up to 10-fold higher in dialysis patients, the proportion of noxPTH on PTHi was significantly higher for all patient groups showing signs of inflammation. However, no strong confounders for PTHi could be identified. The correlation between CRP and the proportion of oxidised PTHi in total PTHi suggests an influence of inflammatory oxidative stress on the proportion of active noxPTH. Apart from the established role of vitamin D, the addition of noxPTH and its proportion of total PTHi in the assessment of unclear PTHi elevations seems reasonable, whereas there is no evidence for the standardised analysis of further parameters such as FGF23 and VDBP.
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